Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tatemachi, Hachioji, Tokyo, 193-0998, Japan.
Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan.
BMC Ophthalmol. 2020 Jun 5;20(1):215. doi: 10.1186/s12886-020-01486-x.
We evaluated the relationship between retinal blood flow and aqueous humor levels of cytokines/growth factors in patients with central retinal vein occlusion (CRVO).
In an observational study, 64 eyes of 64 CRVO patients were examined before anti-vascular endothelial growth factor (VEGF) therapy. Blood flow was assessed in large vessels around and at the optic disk by determining the mean blur rate using laser speckle flowgraphy. Aqueous humor samples were obtained from the patients during anti-VEGF therapy and levels of the following molecules were measured by the suspension array method: soluble VEGF receptor (sVEGFR)-1, sVEGFR-2, VEGF, plancental growth factor (PlGF), platelet-derived growth factor (PDGF)-AA, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, IL-8, IL-12(p70), and IL-13.
The mean blur rate of the affected eye was significantly lower than that of the unaffected eye. The mean blur rate showed a significant negative correlation with the log-transformed aqueous humor levels of PlGF, sICAM-1, and IL-8, but not VEGF.
These findings suggest that retinal blood flow velocity might be more strongly correlated with inflammatory factors than VEGF in patients with nonischemic CRVO and macular edema.
我们评估了中心性视网膜静脉阻塞（CRVO）患者视网膜血流与房水中细胞因子/生长因子水平的关系。
在一项观察性研究中，我们检查了 64 例 CRVO 患者在接受抗血管内皮生长因子（VEGF）治疗前的 64 只眼。通过激光散斑血流图测定平均模糊率来评估大血管周围和视盘处的血流。在抗 VEGF 治疗期间从患者中获得房水样本，并通过悬浮阵列法测量以下分子的水平：可溶性 VEGF 受体（sVEGFR）-1、sVEGFR-2、VEGF、胎盘生长因子（PlGF）、血小板衍生生长因子（PDGF）-AA、可溶性细胞间黏附分子（sICAM）-1、单核细胞趋化蛋白（MCP）-1、白细胞介素（IL）-6、IL-8、IL-12（p70）和 IL-13。
患眼的平均模糊率明显低于健眼。平均模糊率与 PlGF、sICAM-1 和 IL-8 的对数转换房水水平呈显著负相关，但与 VEGF 无关。
这些发现表明，在非缺血性 CRVO 和黄斑水肿患者中，视网膜血流速度可能与炎症因子的相关性强于 VEGF。
