Department of Cardiovascular Medicine, Tokushima University Hospital, 2-50-1 Kuramoto, Tokushima, Japan.
Heart Fail Clin. 2020 Jul;16(3):347-355. doi: 10.1016/j.hfc.2020.02.001.
The key to understanding hemodynamics in heart failure (HF) is the relation between elevated left ventricular (LV) filling pressure and cardiac output. Some patients show abnormal response to stress in the relationship between LV filling pressure and cardiac output. In patients with preserved diastolic function, cardiac output can be increased without significantly elevated filling pressure during stress. In patients with HF, as long as the Frank-Starling mechanism operates effectively, cardiac output can increase while acquiring elevated filling pressure. In patients with decompensated HF, hemodynamic stress will lead to a much greater elevation in filling pressure and pulmonary venous hypertension.
理解心力衰竭（HF）中的血液动力学的关键是左心室（LV）充盈压和心输出量之间的关系。一些患者在 LV 充盈压和心输出量之间的关系中表现出对压力的异常反应。在舒张功能正常的患者中，在压力下，心输出量可以增加而 LV 充盈压不会明显升高。在 HF 患者中，只要 Frank-Starling 机制有效运作，心输出量就可以增加，同时获取升高的充盈压。在失代偿性 HF 患者中，血液动力学压力将导致充盈压和肺静脉高压大大升高。
