肥胖相关性射血分数保留的心力衰竭：病理生理学、诊断和潜在治疗方法。
Obesity-Related Heart Failure with Preserved Ejection Fraction: Pathophysiology, Diagnosis, and Potential Therapies.
机构信息
Department of Cardiovascular Medicine, Gunma University, Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, Gunma 371-8511, Japan.
Department of Cardiovascular Medicine, Gunma University, Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, Gunma 371-8511, Japan.
出版信息
Heart Fail Clin. 2020 Jul;16(3):357-368. doi: 10.1016/j.hfc.2020.02.004.
Obesity is very common in patients with heart failure with preserved ejection fraction (HFpEF). Obesity and increased adiposity have multiple adverse effects on the cardiovascular system, including hemodynamic, inflammatory, mechanical, and neurohormonal effects. Obesity and increased adiposity may be a promising target for therapy in HFpEF. This review summarizes the current understanding of the pathophysiology of obesity-related HFpEF, diagnostic evaluation of HFpEF among obese patients with dyspnea, and potential therapeutic options for the HFpEF obesity phenotype.
肥胖症在射血分数保留型心力衰竭（HFpEF）患者中非常常见。肥胖症和脂肪过多对心血管系统有多种不良影响，包括血流动力学、炎症、机械和神经激素效应。肥胖症和脂肪过多可能是 HFpEF 治疗的一个有前途的靶点。本综述总结了肥胖相关性 HFpEF 的病理生理学、呼吸困难肥胖患者的 HFpEF 诊断评估以及 HFpEF 肥胖表型的潜在治疗选择。
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