Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.
Front Neuroendocrinol. 2020 Jul;58:100850. doi: 10.1016/j.yfrne.2020.100850. Epub 2020 Jun 3.
Women are at significantly greater risk of developing Alzheimer's disease and show higher prevalence of autoimmune conditions relative to men. Women's brain health is historically understudied, and little is therefore known about the mechanisms underlying epidemiological sex differences in neurodegenerative diseases, and how female-specific factors may influence women's brain health across the lifespan. In this review, we summarize recent studies on the immunology of pregnancy and menopause, emphasizing that these major immunoendocrine transition phases may play a critical part in women's brain aging trajectories.
女性患老年痴呆症的风险显著高于男性，且自身免疫性疾病的患病率也相对更高。从历史上看，女性的大脑健康研究不足，因此对于神经退行性疾病中流行病学性别差异的潜在机制以及女性特有的因素如何影响女性在整个生命周期中的大脑健康知之甚少。在这篇综述中，我们总结了近期关于妊娠和绝经免疫的研究，强调这些主要的免疫内分泌转换阶段可能在女性大脑衰老轨迹中起着关键作用。
