Bondy Erin
Department of Psychiatry, University of North Carolina School of Medicine, USA.
Brain Behav Immun Health. 2024 Jul 21;40:100830. doi: 10.1016/j.bbih.2024.100830. eCollection 2024 Oct.
In recent years, a burgeoning field of research has focused on women's mental health and psychiatric conditions associated with perinatal and postpartum periods. An emerging trend points to the link between hormone fluctuations during pregnancy and postpartum that have immunologic consequences in cases of perinatal depression and postpartum psychosis. The transition to menopause (or "perimenopause") has garnered comparatively less attention, but existing studies point to the influential interaction of hormonal and immune pathways. Moreover, the role of this cross talk in perturbing neural networks has been implicated in risk for cognitive decline, but relatively less work has focused on the depressed brain during perimenopause. This brief review brings a psychoneuroimmunology lens to depression during the perimenopausal period by providing an overview of existing knowledge and suggestions for future research to intertwine these bodies of work.
近年来，一个新兴的研究领域聚焦于围产期和产后与女性心理健康及精神疾病相关的问题。一个新出现的趋势表明，孕期和产后激素波动之间存在联系，这在围产期抑郁症和产后精神病病例中具有免疫方面的影响。向更年期（或“围绝经期”）的过渡相对较少受到关注，但现有研究指出了激素和免疫途径之间的相互作用。此外，这种相互作用在扰乱神经网络方面的作用被认为与认知能力下降的风险有关，但相对较少的研究关注围绝经期的抑郁大脑。本简要综述通过概述现有知识以及对未来研究将这些工作结合起来的建议，从心理神经免疫学的角度审视围绝经期的抑郁症。
