Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA.
Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Nat Neurosci. 2024 Nov;27(11):2253-2260. doi: 10.1038/s41593-024-01741-0. Epub 2024 Sep 16.
Pregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans. Leveraging precision imaging, we mapped neuroanatomical changes in an individual from preconception through 2 years postpartum. Pronounced decreases in gray matter volume and cortical thickness were evident across the brain, standing in contrast to increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid, with few regions untouched by the transition to motherhood. This dataset serves as a comprehensive map of the human brain across gestation, providing an open-access resource for the brain imaging community to further explore and understand the maternal brain.
妊娠是数以百万计的女性每年都会经历的一段深刻的激素和生理变化时期，但在人类中，妊娠期间母体大脑中展开的神经变化尚未得到很好的研究。利用精确成像技术，我们对一个人从受孕前到产后 2 年的神经解剖变化进行了映射。整个大脑的灰质体积和皮质厚度明显减少，与白质微观结构完整性、脑室体积和脑脊液的增加形成鲜明对比，只有少数区域没有受到成为母亲的转变的影响。该数据集是妊娠期人类大脑的全面图谱，为脑成像社区提供了一个开放获取资源，以进一步探索和理解母体大脑。
