牙周袋：SARS-CoV-2 的潜在储库？
Periodontal pockets: A potential reservoir for SARS-CoV-2?
机构信息
Department of Periodontology (Rmes U1229, UIC 11), Faculty of Dental Surgery, University of Nantes (CHU de Nantes), Nantes, France; Faculty of Dentistry, McGill University, Montreal, Canada.
Department of Endodontics (Rmes U1229, UIC 11), Faculty of Dental Surgery, University of Nantes (CHU de Nantes), Nantes, France.
出版信息
Med Hypotheses. 2020 Oct;143:109907. doi: 10.1016/j.mehy.2020.109907. Epub 2020 May 30.
Abstract
Periodontal pockets are the major clinical manifestation of Periodontitis, a chronic inflammatory oral disease affecting the teeth-supporting tissues and has high prevalence in the adult population. Periodontal pockets are ideal environments for subgingival bacterial biofilms, that interact with the supragingival oral cavity, mucosal tissues of the pocket and a peripheral circulatory system. Periodontal pockets have been found to harbor viral species such as the Herpes simplex viruses' family. Recently, the SARS-CoV-2 has gained major interest of the scientific/medical community as it caused a global pandemic (Covid-19) and paralyzed the globe with high figures of infected people worldwide. This virus behavior is still partially understood, and by analyzing some of its features we hypothesized that periodontal pocket could be a favorable anatomical niche for the virus and thus acting as a reservoir for SARS-CoV-2.
摘要
牙周袋是牙周炎的主要临床表现，牙周炎是一种影响牙齿支持组织的慢性炎症性口腔疾病，在成年人群中发病率很高。牙周袋是龈下细菌生物膜的理想环境，生物膜与龈上口腔、袋内黏膜组织和外周循环系统相互作用。牙周袋中已发现有疱疹病毒家族等病毒种类。最近，由于引起全球大流行（COVID-19）并使全球数以亿计的人受到感染，SARS-CoV-2 引起了科学界/医学界的极大关注。这种病毒的行为仍部分被理解，通过分析其一些特征，我们假设牙周袋可能是病毒的一个有利的解剖部位，因此充当 SARS-CoV-2 的储库。
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