School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China; Imaging Department of the Affiliated Bethune Hospital of Shanxi Medical University, Taiyuan 030001, PR China.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.
J Inorg Biochem. 2020 Aug;209:111121. doi: 10.1016/j.jinorgbio.2020.111121. Epub 2020 May 26.
Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window exhibits enhanced deep-tissue imaging capability. Likely, cancer therapy in the NIR-II window could provide deeper penetration depth and higher exposure to laser over NIR-I. However, the traditional application of excitation light is still in the NIR-I window. In view of the excellent imaging and therapeutic capabilities of NIR-II window, we have demonstrated a simple polyoxometalate (POM) clusters (molecular formula: (Na)(PMoO) or (NH)(PMoO)), which integrates NIR-II photoacoustic imaging and NIR-II photothermal therapy into an "all-in-one" theranostic nanoplatform, and could be used for PA imaging-guided photothermal therapy in the NIR-II window. In vivo experiments demonstrate that the POM clusters with good water solubility and biocompatibility were effective to kill tumor without recurrence and metastasis under 1064 nm laser illumination.
光声（PA）成像在近红外二区（NIR-II）窗口表现出增强的深层组织成像能力。很可能，NIR-II 窗口中的癌症治疗可以提供比 NIR-I 更深的穿透深度和更高的激光暴露。然而，传统的激发光应用仍然在 NIR-I 窗口。鉴于 NIR-II 窗口的出色成像和治疗能力，我们已经展示了一种简单的多金属氧酸盐（POM）簇（分子式：（Na）（PMoO）或（NH）（PMoO）），它将 NIR-II 光声成像和 NIR-II 光热疗法集成到一个“一体化”的治疗诊断纳米平台中，并可用于 NIR-II 窗口中的 PA 成像引导光热治疗。体内实验证明，具有良好水溶性和生物相容性的 POM 簇在 1064nm 激光照射下可以有效杀死肿瘤，且无复发和转移。
