Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Lampung, Bandar Lampung 35141, Indonesia.
Nanotheranostics. 2024 Aug 1;8(4):506-520. doi: 10.7150/ntno.96286. eCollection 2024.
Photoacoustic imaging is a hybrid modality that combines high-contrast and spectroscopy-based optical imaging specificity with the high spatial resolution of ultrasonography. This review highlights the development and progress of photoacoustic imaging technology over the past decade. This imaging technology has evolved to be more user-friendly, cost-effective, and portable, demonstrating its potential for diverse clinical applications. A potential clinical application lies in the use of photoacoustic imaging as a guiding tool for photothermal therapy. This review was conducted by initially filtering through three databases, namely, Google Scholar, PubMed, and Scopus, resulting in 460 articles published between 2019 and May 2023. Of these, 54 articles were deemed suitable for review after identification. The selected articles were research papers focusing on the development of therapeutic agents that enhance contrast in photoacoustic imaging. All reviewed articles tested these agents both and . This review focuses on wavelength absorption and radiation sources for photothermal therapy. The developed agents predominantly used NIR-I wavelengths, whereas the NIR-II region has been less explored, indicating significant potential for future research. This review provides comprehensive insights into the advancement of compounds serving as therapeutic agents and contrast agents in photoacoustic imaging-guided photothermal therapy.
光声成像是一种混合模态，它将基于高对比度和光谱的光学成像特异性与超声的高空间分辨率相结合。本综述重点介绍了过去十年中光声成像技术的发展和进展。这种成像技术已经变得更加用户友好、经济实惠和便携，展示了其在各种临床应用中的潜力。光声成像在光热治疗中的应用是一个潜在的临床应用。本综述最初通过三个数据库（Google Scholar、PubMed 和 Scopus）进行筛选，共筛选出 2019 年至 2023 年 5 月期间发表的 460 篇文章。其中，经过识别，有 54 篇文章被认为适合综述。选定的文章是专注于开发增强光声成像对比度的治疗剂的研究论文。所有被审查的文章都对这些试剂进行了 和 测试。本综述重点介绍光热治疗的波长吸收和辐射源。开发的试剂主要使用近红外 I 波长，而近红外二区域的研究较少，这表明未来有很大的研究潜力。本综述全面介绍了在光声成像引导光热治疗中作为治疗剂和对比剂的化合物的进展。
