Centro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil.
Centro de Ciências da Saúde, Curso de Medicina, Universidade Estadual do Ceará, Fortaleza, Brazil; Faculdade de Medicina, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universisade Federal do Ceará, Fortaleza, Brazil.
Med Hypotheses. 2020 Nov;144:109899. doi: 10.1016/j.mehy.2020.109899. Epub 2020 May 30.
The coronavirus SARS-CoV-2 pandemia is infecting millions of people and some studies relate conditions that might increase the risk of developing a fatal course for the disease, such as diabetes, cardiovascular diseases and obesity. In COVID-19 physiopathology, one of the main inflammation mechanisms is the "cytokine storm", causing a pro-inflammatory state, related to cardiac and pulmonary damage. There is also a less effective role of lymphocyte B and T in the humoral immunity due to the reduction of their proliferative response. The physiopathology of ASD (Autism Spectrum Disorder) involves several modifications at the genetic and at the immune level, such as the increase of inflammatory cytokines and abnormal immune response in several levels. We hypothesize that ASD could be a risk-factor as the other conditions are.
新型冠状病毒 SARS-CoV-2 大流行正在感染数百万人，一些研究表明，某些疾病可能会增加患致命疾病的风险，如糖尿病、心血管疾病和肥胖症。在 COVID-19 病理生理学中，主要炎症机制之一是“细胞因子风暴”，导致促炎状态，与心脏和肺部损伤有关。淋巴细胞 B 和 T 的体液免疫作用也较弱，因为它们的增殖反应减少。ASD（自闭症谱系障碍）的病理生理学涉及遗传和免疫水平的几个改变，例如炎症细胞因子增加和几个水平的异常免疫反应。我们假设 ASD 可能是一个风险因素，就像其他疾病一样。
