Tseng Chih-Huang, Wang Wen-Chen, Chen Ching-Yi, Hsu Han-Jen, Chen Yuk-Kwan
Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Formos Med Assoc. 2021 Jan;120(1 Pt 2):361-370. doi: 10.1016/j.jfma.2020.05.025. Epub 2020 Jun 3.
BACKGROUND/PURPOSE: Due to the rarity of oral lymphoma (OL), we aimed to evaluate the clinical features of OL and discuss these findings in light of the literature.
English language literature (1980-2019) related to OL was searched in two electronic databases. Patients (2000-2019) diagnosed with OL were also selected from the database of the Oral Pathology Department in our institution. The clinical features, radiographic appearance, and histopathological diagnosis in these selected cases from publications and our institution were then analyzed.
607 cases of OL (15 in our institution and 592 from literature) in patients aged between 0 and 92 years (average, 51.8 years) with a male to female ratio of 1.6:1 were included. The most common diagnosis was diffuse large B-cell lymphoma (n = 205), followed by Burkitt lymphoma (n = 72) and T-cell lymphoma (n = 37). The most frequent site was the gingiva, followed by palate, maxilla, mandible, tongue and buccal mucosa. The most frequent symptoms were swelling, ulceration, paresthesia, mobile tooth and pain. Radiographic findings included ill-defined osteolytic lesion, thickening of the periodontal ligament, loss of lamina dura and tooth displacement.
Despite the rarity of extranodal lymphomas in oral cavity, their occurrence may be part of disseminated disease. Detailed history-taking, clinical and imaging examination and awareness of the patient's signs and symptoms are important for early diagnosis and an improved prognosis. The current data form a useful basis for clinical investigation and teaching regarding lymphoma occurring in the oral cavity.
背景/目的：由于口腔淋巴瘤（OL）较为罕见，我们旨在评估OL的临床特征，并结合文献对这些发现进行讨论。
在两个电子数据库中检索1980 - 2019年与OL相关的英文文献。还从我们机构口腔病理科的数据库中选取了2000 - 2019年被诊断为OL的患者。然后对这些来自出版物和我们机构的选定病例的临床特征、影像学表现和组织病理学诊断进行分析。
纳入了607例OL患者（15例来自我们机构，592例来自文献），年龄在0至92岁之间（平均51.8岁），男女比例为1.6:1。最常见的诊断是弥漫性大B细胞淋巴瘤（n = 205），其次是伯基特淋巴瘤（n = 72）和T细胞淋巴瘤（n = 37）。最常见的发病部位是牙龈，其次是腭部、上颌骨、下颌骨、舌和颊黏膜。最常见的症状是肿胀、溃疡、感觉异常、牙齿松动和疼痛。影像学表现包括边界不清的溶骨性病变、牙周膜增厚、硬骨板丧失和牙齿移位。
尽管口腔结外淋巴瘤罕见，但其发生可能是播散性疾病的一部分。详细的病史采集、临床和影像学检查以及对患者体征和症状的认识对于早期诊断和改善预后很重要。目前的数据为口腔淋巴瘤的临床研究和教学提供了有用的基础。
