Salma U, Sultana S, Saha S K, Ahmed S M, Salma M U, Nahar K, Ahmed S M
Dr Umme Salma, M Phil Pharmacology (Thesis Part Student), Mymensingh Medical College (MMC), Mymensingh, Bangladesh.
Mymensingh Med J. 2020 Apr;29(2):248-253.
Cinnamomum zeylanicum as medicinal plants are measured as new resources for preparing elements in the treatment of antibiotic-resistant microbes as alternatives to antibiotics. This study was aimed to evaluate the antibacterial activity of ethanol extracts of Cinnamomum zeylanicum against a Gram-negative bacteria Pseudomonas aeruginosa. This experimental study was carried out in the department of Pharmacology & Therapeutics and department of Microbiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2017 to July 2018. Evaluation of the in vitro antibacterial activity of ethanol extracts of Cinnamomum zeylanicum against Pseudomonas aeruginosa was performed by disc diffusion method. And also in this study we used broth dilution method to determine the minimum inhibitory concentration (MIC). Ethanol cinnamon extract (ECE) was found active against P. aeruginosa. Zone of inhibition (ZOI) ranged between 6-25mm at different concentration of extracts. The MIC was 0.3g/ml. Cinnamomum zeylanicum showed strong antibacterial activity against a Gram-negative bacteria Pseudomonas aeruginosa. The results may contribute to the development of potential antimicrobial agents for inclusion in antipseudomonal regimens.
作为药用植物，锡兰肉桂被视为制备治疗抗生素耐药微生物成分的新资源，可作为抗生素的替代品。本研究旨在评估锡兰肉桂乙醇提取物对革兰氏阴性菌铜绿假单胞菌的抗菌活性。本实验研究于2017年7月至2018年7月在孟加拉国迈门辛医学院药理学与治疗学系及微生物学系进行。采用纸片扩散法评估锡兰肉桂乙醇提取物对铜绿假单胞菌的体外抗菌活性。并且在本研究中我们还使用肉汤稀释法来测定最低抑菌浓度（MIC）。发现乙醇肉桂提取物（ECE）对铜绿假单胞菌有活性。在不同浓度提取物下，抑菌圈（ZOI）范围为6 - 25毫米。MIC为0.3克/毫升。锡兰肉桂对革兰氏阴性菌铜绿假单胞菌表现出较强的抗菌活性。这些结果可能有助于开发潜在的抗菌剂，用于抗假单胞菌治疗方案。
