Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, People's Republic of China.
Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Shenyang, Liaoning, 110001, People's Republic of China.
Int J Cardiovasc Imaging. 2020 Oct;36(10):1931-1939. doi: 10.1007/s10554-020-01908-3. Epub 2020 Jun 6.
Pulse wave velocity (PWV) measured by ultrafast ultrasound imaging can early evaluate arteriosclerosis. The study aimed to establish normal reference range for ufPWV in healthy adults and explore its influencing factors, and evaluate the ufPWV changes on coronary slow flow (CSF). ufPWV at the beginning and end of systole (ufPWV-BS and ufPWV-ES, respectively) was measured in healthy adults (201 cases). CSF was diagnosed based on thrombolysis in myocardial infarction (TIMI) frame count during coronary angiography. ufPWV-BS and ufPWV-ES were compared between CSF (50 cases) and control groups (50 healthy age-, body mass index-, and blood pressure-matched adults). In healthy adults, average ufPWV-BS and ufPWV-ES was 5.36 ± 1.27 m/s and 6.99 ± 1.93 m/s, respectively. ufPWV-BS and ufPWV-ES positively correlated with age, body mass index, and blood pressure. ufPWV-BS and ufPWV-ES in the CSF group were higher than in the control group (ufPWV-BS, 6.05 ± 1.07 vs. 5.26 ± 0.89 m/s, P < 0.001; ufPWV-ES, 9.07 ± 1.84 vs. 6.84 ± 1.08 m/s, P < 0.001). Receiver operating characteristic curves showed that ufPWV-ES was more sensitive than ufPWV-BS. The normal reference range of ufPWV for healthy adults was established. Age, body mass index, and blood pressure were the main influencing factors. ufPWV was increased in the patients with CSF. The findings indicated that, in addition to reflecting atherosclerosis, ufPWV might also provide a basis for the noninvasive evaluation of microvascular impairment in the patients with CSF.
脉搏波速度（PWV）通过超快速超声成像测量，可以早期评估动脉硬化。本研究旨在建立健康成年人中超快速 PWV 的正常参考范围，并探讨其影响因素，以及评估超快速 PWV 对冠状动脉慢血流（CSF）的变化。在健康成年人中（201 例）测量收缩期开始和结束时的 ufPWV（ufPWV-BS 和 ufPWV-ES）。根据冠状动脉造影时心肌梗死溶栓治疗（TIMI）帧数诊断 CSF。将 CSF（50 例）与对照组（50 例年龄、体重指数和血压匹配的健康成年人）的 ufPWV-BS 和 ufPWV-ES 进行比较。在健康成年人中，平均 ufPWV-BS 和 ufPWV-ES 分别为 5.36±1.27 m/s 和 6.99±1.93 m/s。ufPWV-BS 和 ufPWV-ES 与年龄、体重指数和血压呈正相关。CSF 组的 ufPWV-BS 和 ufPWV-ES 高于对照组（ufPWV-BS，6.05±1.07 vs. 5.26±0.89 m/s，P<0.001；ufPWV-ES，9.07±1.84 vs. 6.84±1.08 m/s，P<0.001）。受试者工作特征曲线显示 ufPWV-ES 比 ufPWV-BS 更敏感。建立了健康成年人 ufPWV 的正常参考范围。年龄、体重指数和血压是主要影响因素。CSF 患者的 ufPWV 增加。研究结果表明，ufPWV 除了反映动脉硬化外，还可能为 CSF 患者微血管损伤的无创评估提供依据。
