Ma Xuehui, Zhu Zhengqiu, Wang Yinping, Shen Bixiao, Jiang Xuezhong, Liu Wenjun, Wu Yiyun, Zou Chong, Luan Yun, Gao Hui, Huang Hui
Department of Ultrasound, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
Department of Ultrasound, Jiangsu Province Geriatric Hospital, Geriatric Hospital of Nanjing Medical University, Nanjing, China.
Ultrasonography. 2023 Jan;42(1):89-99. doi: 10.14366/usg.22039. Epub 2022 Jul 9.
The aim of this study was to assess carotid stiffening in a pre-hypertensive (PHT) population using ultrafast pulse wave velocity (ufPWV).
This study retrospectively enrolled 626 individuals who underwent clinical interviews, serum tests, and assessments of the systolic blood pressure (SBP), diastolic blood pressure (DBP), carotid intima-media thickness (cIMT), pulse wave velocity-beginning of systole (PWV-BS), and pulse wave velocity-end of systole (PWV-ES) between January 2017 and December 2021. The patients were divided into three groups according to their blood pressure (BP)-normal BP (NBP): SBP <130 mmHg and DBP <80 mmHg (n=215); PHT: 130 mmHg≤SBP<140 mmHg and/or 80 mmHg≤DBP<90 mmHg (n=119); hypertensive (HT): SBP ≥140 mmHg and/or DBP ≥90 mmHg (n=292). Correlation analyses and comparisons were performed among the groups and in the cIMT subgroups (cIMT ≥0.050 cm and <0.050 cm).
cIMT and PWV-ES significantly differed among the BP groups (P<0.05). The BP groups had similar PWV-BS when cIMT <0.050 cm or cIMT ≥0.050 cm (all P>0.05). However, the NBP group had a notably lower PWV-ES than the PHT (P<0.001 and P=0.024) and HT (all P<0.001) groups in both cIMT categories, while the PWV-ES in the PHT group were not significantly lower than in the HT group (all P>0.05).
Carotid morphological and biomechanical properties in the PHT group differed from those in the NBP group. ufPWV could be used for an early evaluation of carotid stiffening linked to pre-hypertension.
本研究旨在使用超快速脉搏波速度（ufPWV）评估高血压前期（PHT）人群的颈动脉僵硬度。
本研究回顾性纳入了626名在2017年1月至2021年12月期间接受临床访谈、血清检测以及收缩压（SBP）、舒张压（DBP）、颈动脉内膜中层厚度（cIMT）、收缩期开始时脉搏波速度（PWV-BS）和收缩期末脉搏波速度（PWV-ES）评估的个体。根据血压将患者分为三组——正常血压（NBP）：SBP<130 mmHg且DBP<80 mmHg（n = 215）；高血压前期（PHT）：130 mmHg≤SBP<140 mmHg和/或80 mmHg≤DBP<90 mmHg（n = 119）；高血压（HT）：SBP≥140 mmHg和/或DBP≥90 mmHg（n = 292）。在各组之间以及cIMT亚组（cIMT≥0.050 cm和<0.050 cm）中进行相关性分析和比较。
BP组之间的cIMT和PWV-ES存在显著差异（P<0.05）。当cIMT<0.050 cm或cIMT≥0.050 cm时，BP组的PWV-BS相似（所有P>0.05）。然而，在两个cIMT类别中，NBP组的PWV-ES均显著低于PHT组（P<0.001和P = 0.024）和HT组（所有P<0.001），而PHT组的PWV-ES并不显著低于HT组（所有P>0.05）。
PHT组的颈动脉形态和生物力学特性与NBP组不同。ufPWV可用于早期评估与高血压前期相关的颈动脉僵硬度。
