Soni S D, Wiles D, Schiff A A, Bamrah J S
Psychiatric Research Department, Salford Health Authority, Prestwich Hospital, Manchester.
Br J Psychiatry. 1988 Sep;153:382-4. doi: 10.1192/bjp.153.3.382.
Depot neuroleptics are now commonly used for maintenance therapy of schizophrenia. Their physicochemical composition makes them ideal for such use because they are long-acting and show stable blood levels for prolonged periods. Their absorption from the site of injection may, however, be affected by local muscle factors. This paper describes three such factors in relation to fluphenazine decanoate: varying the site of injection; massage of the injection site; and effects of muscular exercise. Our results suggest that fluphenazine pharmacokinetics are not significantly affected by any of these factors.
长效抗精神病药物目前常用于精神分裂症的维持治疗。它们的物理化学组成使其非常适合这种用途，因为它们作用时间长，且在较长时间内血药浓度稳定。然而，它们从注射部位的吸收可能会受到局部肌肉因素的影响。本文描述了与癸酸氟奋乃静相关的三个这样的因素：改变注射部位；按摩注射部位；以及肌肉运动的影响。我们的结果表明，这些因素均未对氟奋乃静的药代动力学产生显著影响。
