腕踝针联合氟西汀治疗脑卒中后抑郁随机对照临床研究。

Wrist-ankle acupuncture and Fluoxetine in the treatment of post-stroke depression: a randomized controlled clinical trial.

机构信息

Department of Traditional Chinese Medicine, Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China.

Acupuncture-Moxibustion and Tuina, Shanghai university of Traditional Chinese Medicine, Shanghai 201203, China.

出版信息

J Tradit Chin Med. 2020 Jun;40(3):455-460. doi: 10.19852/j.cnki.jtcm.2020.03.014.

DOI:10.19852/j.cnki.jtcm.2020.03.014

PMID:32506860

Abstract

OBJECTIVE

To investigate the effects of WAA combined with fluoxetine in the clinical treatment of post-stroke depression (PSD) .

METHODS

In this randomized, controlled and single-blind trial, 105 PSD patients who met the inclusion criteria were randomly divided into three equal groups: Thin wrist-ankle acupuncture (WAA) group (Thin WAA needle + Fluoxetine), Thick WAA group (Thick WAA needle + Fluoxetine), and Sham WAA group (sham WAA needle + Fluoxetine). In this trial, the primary outcome was Hamilton Depression Scale (HAMD), while the secondary outcomes included Zung self-rating depression scale (SDS) and World Health Organization Quality of Life BREF (QQL).

RESULTS

Ninety nine PSD patients completed all the treatment. The HAMD scores and SDS scores of all the three groups decreased after treatment (P < 0.05); thick WAA group and thin WAA group decreased more obviously than the sham WAA group (P < 0.05). There was no significant difference between the QQL scores of the three groups (P > 0.05). There was no significant difference in the scores of the three scales between the thick wrist ankle needles and the thin wrist ankle needles (P > 0.05).

CONCLUSION

The present study showed that WAA combined with fluoxetine can relieve the symptoms of depression after stroke. WAA therapy could improve the antidepressant effect of fluoxetine.

摘要

目的

观察腕踝针联合氟西汀治疗脑卒中后抑郁（PSD）的临床疗效。

方法

本研究采用随机、对照、单盲的临床试验设计，纳入符合标准的 PSD 患者 105 例，按随机数字表法分为三组，每组 35 例。三组均给予氟西汀治疗，腕踝针组（细腕踝针+氟西汀）、粗腕踝针组（粗腕踝针+氟西汀）和假腕踝针组（假腕踝针+氟西汀）分别给予细腕踝针、粗腕踝针和假腕踝针治疗。本研究以汉密尔顿抑郁量表（HAMD）为主要结局指标，以 Zung 氏抑郁自评量表（SDS）和世界卫生组织生存质量测定量表简表（QOL-BREF）为次要结局指标。

结果

99 例 PSD 患者完成全部治疗。三组治疗后 HAMD 评分和 SDS 评分均较治疗前降低（P<0.05），且粗腕踝针组和细腕踝针组的 HAMD 评分和 SDS 评分降低幅度大于假腕踝针组（P<0.05）；三组患者 QOL-BREF 评分差异无统计学意义（P>0.05）。三组间各量表评分差异无统计学意义（P>0.05）。粗腕踝针组与细腕踝针组间各量表评分差异亦无统计学意义（P>0.05）。