Department of Ophthalmology, Nowon Eulji Medical Center, Eulji University , Seoul, Korea.
Department of Ophthalmology, Seoul National University College of Medicine , Seoul, Korea.
Ophthalmic Epidemiol. 2020 Dec;27(6):460-467. doi: 10.1080/09286586.2020.1773870. Epub 2020 Jun 8.
This study aimed to determine the incidence, prevalence, and etiologies of third cranial nerve (CN3) palsy in Koreans.
Data were collected from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database of South Korea and analyzed. Incident CN3 palsy subjects in the cohort population were defined as cases occurring after the initial 4-year or longer washout period. The incidence and prevalence were analyzed by sex, age group, and year. The etiologies of CN3 palsy were evaluated using comorbidities.
Of 1,108,253 subjects, 387 patients were newly diagnosed with CN3 palsy between 2006 and 2015. The incidence of CN3 palsy was 3.71 per 100,000 person-years (95% confidence interval, 3.35-4.09). The incidence of CN3 palsy increased with age and accelerated after the age of 60 years. The mean male-to-female incidence ratio was 1.16. The main cause was presumed to be vascular disease (52.7%), followed by idiopathic causes (25.8%), intracranial neoplasm (7.8%), unruptured cerebral aneurysm (5.4%), and trauma (5.2%).
The incidence of CN3 palsy in Koreans increased with age and peaked between 75 and 79 years. The main cause of CN3 palsy was vascular disease.
本研究旨在确定韩国第三颅神经（CN3）麻痹的发病率、患病率和病因。
数据来自韩国国家健康保险服务-国家样本队列（NHIS-NSC）数据库，并进行了分析。队列人群中新发 CN3 麻痹患者定义为在最初的 4 年或更长的洗脱期后发生的病例。通过性别、年龄组和年份分析发病率和患病率。使用合并症评估 CN3 麻痹的病因。
在 1108253 名受试者中，387 名患者在 2006 年至 2015 年间被新诊断为 CN3 麻痹。CN3 麻痹的发病率为 3.71/100000 人年（95%置信区间，3.35-4.09）。CN3 麻痹的发病率随年龄增长而增加，并在 60 岁后加速。男女发病率比为 1.16。主要原因被认为是血管疾病（52.7%），其次是特发性原因（25.8%）、颅内肿瘤（7.8%）、未破裂脑动脉瘤（5.4%）和创伤（5.2%）。
韩国 CN3 麻痹的发病率随年龄增长而增加，75 至 79 岁时达到峰值。CN3 麻痹的主要病因是血管疾病。
