Department of Ophthalmology, Hallym University School of Medicine, Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Sci Rep. 2022 Jun 22;12(1):10512. doi: 10.1038/s41598-022-14621-z.
To assess association between migraines and development of ocular motor cranial nerve palsy (CNP) and finding risk factors using the National Sample Cohort database from the Korea National Health Insurance Service. Data was analyzed from 4,234,341 medical screening examinees aged 20-90 years in 2009. Cox proportional hazard regression analysis was used to the adjusted hazard ratios (HR) for ocular motor CNP according to presence of migraine. Subgroup analysis was performed to evaluate effect of other factors on association of migraine with ocular motor CNP. A total of 5806 participants (0.14% of subjects) developed ocular motor CNP and were assigned to CNP group, 4,048,018 were assigned to control group, with an average of 8.22 ± 0.93 years of follow-up. Incidence of ocular motor CNP increased in migraine group compared to control. After adjusting potential confounding variables, HR for ocular motor CNP was 1.166 (confidence interval [CI] 1.013-1.343) in migraine group. Subgroups of relatively younger age less than 65 years (HR = 1.267, 95% CI 1.067-1.504), male gender (HR = 1.228, 95% CI 1.000-1.122), smokers (HR 1.426, 95% CI 1.127-1.803), and diabetes mellitus patients (HR = 1.378, 95% CI 1.045-1.378) showed a stronger association between migraines and development of ocular motor CNP. Our population-based cohort study demonstrated a significant association between presence of migraines and incidence of ocular motor CNP. Especially, relatively younger age, males, smokers, and diabetes patients with migraines could have a higher risk of developing ocular motor CNP.
为了评估偏头痛与眼动颅神经麻痹（CNP）的发展之间的关联，并使用韩国国家健康保险服务的国家样本队列数据库寻找风险因素。对 2009 年 20-90 岁的 4234341 名医学筛查受检者的数据进行了分析。使用 Cox 比例风险回归分析对存在偏头痛的眼动 CNP 的调整后危险比（HR）进行了分析。进行了亚组分析，以评估其他因素对偏头痛与眼动 CNP 之间关联的影响。共有 5806 名参与者（受试者的 0.14%）发生眼动 CNP，并被分配到 CNP 组，4048018 名被分配到对照组，平均随访 8.22±0.93 年。与对照组相比，偏头痛组眼动 CNP 的发生率增加。在调整潜在混杂变量后，偏头痛组眼动 CNP 的 HR 为 1.166（95%CI 1.013-1.343）。年龄较小（<65 岁）（HR=1.267，95%CI 1.067-1.504）、男性（HR=1.228，95%CI 1.000-1.122）、吸烟者（HR 1.426，95%CI 1.127-1.803）和糖尿病患者（HR=1.378，95%CI 1.045-1.378）的亚组中，偏头痛与眼动 CNP 的发展之间存在更强的关联。我们的基于人群的队列研究表明，偏头痛的存在与眼动 CNP 的发生率之间存在显著关联。特别是年龄较小、男性、吸烟者和患有糖尿病的偏头痛患者发生眼动 CNP 的风险可能更高。
