车前草糖浆治疗头颈部癌症患者放射性口腔黏膜炎的疗效：一项随机、双盲、安慰剂对照的临床试验。
Efficacy of the plantago major L. syrup on radiation induced oral mucositis in head and neck cancer patients: A randomized, double blind, placebo-controlled clinical trial.
机构信息
Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran.
Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Complement Ther Med. 2020 Jun;51:102397. doi: 10.1016/j.ctim.2020.102397. Epub 2020 Apr 30.
INTRODUCTION
Oral mucositis is a complication of radiation therapy in cancer patients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancer patients.
METHODS
In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23 patients received placebo syrup as control group for 7 weeks. Outcome measures were severity of mucositis according to WHO scale and severity of patients' pain assessed by visual analogue scale.
RESULTS
Severity of mucositis were significantly lower in intervention group compared to placebo group (p value<0.05). Also patients in intervention group experienced significantly less pain compared to placebo group during radiotherapy period (p value<0.05) CONCLUSION: Plantago major L syrup was effective on the reduction of the symptoms of radiation induced mucositis in patients with head and neck cancers.
简介
口腔黏膜炎是癌症患者放疗的一种并发症。我们设计了一项试验来评估车前草对癌症患者放射性黏膜炎症状的疗效。
方法
在这项随机、双盲、安慰剂对照试验中，23 名患者接受车前草糖浆作为干预组，23 名患者接受安慰剂糖浆作为对照组，持续 7 周。评估指标为根据世界卫生组织（WHO）标准评估的黏膜炎严重程度和视觉模拟评分法（VAS）评估的患者疼痛严重程度。
结果
与安慰剂组相比，干预组的黏膜炎严重程度显著降低（p 值<0.05）。此外，在放疗期间，干预组患者的疼痛程度明显低于安慰剂组（p 值<0.05）。
结论
车前草糖浆对减少头颈部癌症患者放射性黏膜炎的症状有效。
Zotero 插件