Hegde Sanath Kumar, Rao Suresh, Rao Pratima, Raghu Shamprasad Varija, Meera Sharake, Baliga Manjeshwar Shrinath
Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore, 575002 India.
Department of Dentistry, Mangalore Institute of Oncology, Mangalore, 575002 India.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6330-6338. doi: 10.1007/s12070-021-03059-w. Epub 2022 Jan 11.
Mucositis is a very painful unavoidable and common side effect in head and neck cancer patients undergoing curative radiotherapy and can affect the planned treatment. In this study, attempt is made at understanding the efficacy of Linn (amla) when combined with providone iodine in mitigating radiation-induced mucositis, weight loss and tumor control. This was a retrospective chart based study and was carried out by extracting the data from the files of patients with cancer of head and neck who used amla in combination with iodine or iodine alone during the course of the curative radiotherapy (> 60 Gy). The data was entered in to Microsoft excel and subjected to statistical analysis using SPSS 17 software. The results indicate that when compared with iodine alone, the group where iodine and amla gargling were used was very effective in delaying mucositis, reduced incidence of intolerable mucositis ( = 0.027), quantitative grade of weight loss ( = 0.016), incidence of severe weight loss ( = 0.03) without affecting tumor response. The results suggest that when compared with iodine alone, amla when combined with iodine was more effective in mitigating radiation mucositis and by not interfering with the tumor cell kill. As far as the authors are aware of this is the first study that shows the usefulness of combining iodine with Amla in mitigating radiation-induced mucositis.
口腔黏膜炎是接受根治性放疗的头颈癌患者中一种非常疼痛、不可避免且常见的副作用，会影响计划中的治疗。在本研究中，尝试了解余甘子（印度醋栗）与聚维酮碘联合使用在减轻放射性口腔黏膜炎、体重减轻和肿瘤控制方面的疗效。这是一项基于回顾性病历的研究，通过从接受根治性放疗（>60 Gy）期间使用余甘子与碘联合或仅使用碘的头颈癌患者档案中提取数据来进行。数据录入Microsoft Excel，并使用SPSS 17软件进行统计分析。结果表明，与仅使用碘相比，使用碘和余甘子含漱的组在延迟口腔黏膜炎、降低无法耐受的口腔黏膜炎发生率（=0.027）、体重减轻的定量分级（=0.016）、严重体重减轻的发生率（=0.03）方面非常有效，且不影响肿瘤反应。结果表明，与仅使用碘相比，余甘子与碘联合使用在减轻放射性口腔黏膜炎方面更有效，且不干扰肿瘤细胞杀伤。据作者所知，这是第一项显示碘与余甘子联合使用在减轻放射性口腔黏膜炎方面有用性的研究。
