猫尿液脂质代谢物特征。
The profile of urinary lipid metabolites in cats.
机构信息
Department of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
J Vet Med Sci. 2020 Jul 31;82(7):1017-1020. doi: 10.1292/jvms.20-0238. Epub 2020 Jun 5.
Polyunsaturated fatty acids including arachidonic acid (AA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are converted to lipid mediators by oxidation. Unlike other mammals, cats cannot synthesize AA. Since their lipid metabolic features remain unknown, we qualitatively analyzed 118 types of urinary lipid metabolites in healthy neutered cats. Using LC-MS, we found 26 lipid metabolites in urines of all individuals. In detail, 20 AA-, 5 EPA- and 1 DHA-derived lipid mediators were detected. Focusing on oxidative pathway, 17 cyclooxygenase-metabolites and 5 metabolites produced by non-enzymatic pathway were detected. Of interest, few lipoxygenase- or cytochrome P450-metabolites were excreted. Thus, AA-derived cyclooxygenase-metabolites mainly composed the urinary lipid metabolites in cats.
多不饱和脂肪酸包括花生四烯酸（AA）、二十二碳六烯酸（DHA）和二十碳五烯酸（EPA），可通过氧化转化为脂质介质。与其他哺乳动物不同，猫不能合成 AA。由于它们的脂质代谢特征尚不清楚，我们定性分析了健康去势猫的 118 种尿脂质代谢物。使用 LC-MS，我们在所有个体的尿液中发现了 26 种脂质代谢物。详细来说，检测到 20 种 AA、5 种 EPA 和 1 种 DHA 衍生的脂质介质。关注氧化途径，检测到 17 种环氧化酶代谢物和 5 种非酶途径产生的代谢物。有趣的是，很少有脂氧合酶或细胞色素 P450 代谢物被排泄。因此，AA 衍生的环氧化酶代谢物主要构成了猫尿中的脂质代谢物。
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