Department of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Koyama Animal Hospital, Tochigi, Japan.
J Vet Med Sci. 2022 May 17;84(5):689-693. doi: 10.1292/jvms.22-0049. Epub 2022 Apr 5.
Although feline idiopathic cystitis (FIC) distresses of many cats, its pathogenesis is unknown and the diagnosis is challenging. Polyunsaturated fatty acids (PUFAs) are metabolized into various lipid mediators. Lipid mediators such as prostaglandins (PGs) modulate inflammation and many of them are excreted into the urine. Thus, the investigation of the urinary lipid profile may reveal pathogenesis and help diagnosis of FIC. We collected urine samples from five FIC cats by spontaneous urination and analyzed 158 types of lipid mediators in urines using liquid chromatography-mass spectrometry. The urinary levels of PUFAs were higher in FIC compared to those of the healthy group. The excretions of a major inflammatory mediator, PGD, were less in FIC. Other well-known inflammatory mediators such as PGE, PGI, and their metabolites did not show a difference. In contrast, the levels of PGF and its 2 metabolites and PGF were higher in FIC. These results may provide new insights into the future management of cat FIC.
尽管猫特发性膀胱炎（FIC）会使许多猫感到不适，但它的发病机制尚不清楚，诊断也具有挑战性。多不饱和脂肪酸（PUFAs）可代谢为各种脂质介质。脂质介质，如前列腺素（PGs），可调节炎症，其中许多被排泄到尿液中。因此，对尿液脂质谱的研究可能揭示发病机制并有助于 FIC 的诊断。我们通过自发性排尿收集了五例 FIC 猫的尿液样本，并使用液相色谱-质谱法分析了尿液中的 158 种脂质介质。与健康组相比，FIC 组的 PUFAs 水平更高。FIC 中 PGD 的排泄量较少，而其他众所周知的炎症介质，如 PGE、PGI 及其代谢物则没有差异。相比之下，PGF 及其 2 种代谢物和 PGF 的水平在 FIC 中更高。这些结果可能为猫 FIC 的未来管理提供新的思路。
