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2020年临床与转化医学的新焦点

New focuses of clinical and translational medicine in 2020.

作者信息

Cheng Xin, Wu Duojiao, Cheng Yunfeng, Qiao Tiankui, Wang Xiangdong

机构信息

Centre for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University Shanghai Medical College, Shanghai, China.

出版信息

Clin Transl Med. 2020 Jan;10(1):17-19. doi: 10.1002/ctm2.9. Epub 2020 Mar 31.

DOI:10.1002/ctm2.9
PMID:32508045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7240855/
Abstract

Clinical and translational medicine is an ongoing opportunity and challenge to transition science from bench to patient, from patient to bench, and from patient to policy for scientists and clinicians. Of the many objectives, the most important one is to improve the quality of life in patients, including living duration, dignity, emotional well-being, psychiatric and physical health, as well as independency. Emphasis and redefining concepts has allowed clinical and translational medicine to experience exciting and productive developments. Further discoveries, innovations, validations, and developments in clinical and translational medicine are expected in 2020. The present editorial aims to present the top three most discussed topics with high expectations for translation from clinical investigations and trials into practice and application.

摘要

临床与转化医学对于科学家和临床医生而言,是一个将科学从实验室转化到患者、从患者反馈到实验室、从患者需求转化为政策的持续机遇与挑战。在众多目标中,最重要的是提高患者的生活质量,包括生存期、尊严、情感幸福、精神和身体健康以及独立性。重点和概念的重新定义使临床与转化医学取得了令人振奋且富有成效的发展。预计2020年临床与转化医学将有更多的发现、创新、验证和发展。本社论旨在介绍最受讨论的三大主题,对从临床研究和试验到实践与应用的转化寄予厚望。

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New focuses of clinical and translational medicine in 2020.2020年临床与转化医学的新焦点
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Molecular mechanisms, off-target activities, and clinical potentials of genome editing systems.基因组编辑系统的分子机制、脱靶活性及临床应用潜力
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本文引用的文献

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Artificial intelligence in clinical and genomic diagnostics.人工智能在临床和基因组诊断中的应用。
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Search-and-replace genome editing without double-strand breaks or donor DNA.无双链断裂或供体 DNA 的搜索和替换基因组编辑。
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Toward Clinical Implementation of Next-Generation Sequencing-Based Genetic Testing in Rare Diseases: Where Are We?迈向罕见病下一代测序基因检测的临床应用:我们在哪里?
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Cancer modeling meets human organoid technology.癌症建模与人类类器官技术相遇。
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Adopt a moratorium on heritable genome editing.暂停可遗传的基因组编辑。
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Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.外周血淋巴细胞与肿瘤类器官共培养生成肿瘤反应性 T 细胞
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