Lakkam Bhagirathi D, Astekar Madhusudan, Alam Shakir, Sapra Gaurav, Agarwal Ashutosh, Agarwal Aditi Murari
Department of Oral Pathology and Microbiology, Sri Sai Krupa Dental Clinic, Gulbarga, Karnataka, India.
Department of Oral Pathology and Microbiology, Bareilly International University, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):76-80. doi: 10.4103/jomfp.JOMFP_350_19. Epub 2020 May 8.
Focal fibrous hyperplasia, peripheral ossifying fibroma, pyogenic granuloma, peripheral giant cell granuloma, giant cell fibroma and focal reactive overgrowth (FROGs) are one of the foremost numerous benign soft-tissue growths in the oral cavity. Chronic irritation or trauma is with identified as the causative aspect. It may develop up to few centimeters in diameter, pedunculated or sessile and may arise on the gingiva or buccal mucosa. Treatment involves surgical excision, and recurrences are infrequent.
The aim of this study was to assess the prevalence of FROGs of oral mucosa in an institutional setup.
All the histopathologically diagnosed cases of FROGs within a period of 10 years (January 2008-December 2017) were retrieved from the archives of the Department of Oral Pathology. The information such as age, sex, site, anatomical side and its prevalence were recorded on customized case history performa.
The significance of difference was assessed using the Chi-square test and Fisher's exact test.
A total of 2849 cases were identified, of which 449 (15%) were FROGs. The most prevalent lesion amid them were focal fibrous hyperplasia (277, 62%), followed by pyogenic granuloma (92, 20%), whereas the least common was giant cell fibroma with 2 (0.5%) cases. All the FROGs were distributed among 21-40 years of age showing female predominance. The commonly affected site was the right buccal mucosa.
Nevertheless, information of the frequency and distribution of these lesions is favorable when establishing a diagnosis and treatment plan in clinical practice.
局灶性纤维增生、外周骨化性纤维瘤、化脓性肉芽肿、外周巨细胞肉芽肿、巨细胞纤维瘤和局灶性反应性过度增生（FROGs）是口腔中最常见的良性软组织增生之一。慢性刺激或创伤被认为是致病因素。其直径可达几厘米，有蒂或无蒂，可发生于牙龈或颊黏膜。治疗方法为手术切除，复发情况不常见。
本研究的目的是评估在机构环境中口腔黏膜FROGs的患病率。
从口腔病理科档案中检索出10年期间（2008年1月至2017年12月）所有经组织病理学诊断为FROGs的病例。将年龄、性别、部位、解剖侧别及其患病率等信息记录在定制的病历表格上。
采用卡方检验和Fisher精确检验评估差异的显著性。
共识别出2849例病例，其中449例（15%）为FROGs。其中最常见的病变是局灶性纤维增生（277例，62%），其次是化脓性肉芽肿（92例，20%），而最不常见的是巨细胞纤维瘤，有2例（0.5%）。所有FROGs均分布于21至40岁年龄段，女性占优势。最常受累的部位是右侧颊黏膜。
然而，在临床实践中制定诊断和治疗方案时，了解这些病变的频率和分布信息是有益的。
