一项针对 2971 例牙龈瘤病例的大队列研究：重点关注与复发相关的危险因素。

A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence.

机构信息

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Stomatological Hospital and Dental School of Tongji University, Shanghai, 200072, P. R. China.

Biostatistics Office of Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.

出版信息

BMC Oral Health. 2023 Apr 20;23(1):229. doi: 10.1186/s12903-023-02935-x.

DOI:10.1186/s12903-023-02935-x

PMID:37081478

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10116732/

Abstract

BACKGROUND

To analyze the clinicopathological features of different histological subtypes of epulis, and evaluate the risk factors associated with recurrence.

MATERIALS AND METHODS

A retrospective study including 2971 patients was performed. The patients' sex, age, location, size, histological subtypes, recurrence information, oral hygiene habits, periodontitis symptoms and smoking history were retrieved from the patient medical records and follow-up information.

RESULTS

Among the 2971 cases, focal fibrous hyperplasia (FFH) was the most common lesion (60.92%), followed by peripheral ossifying fibroma (POF) (29.32%), pyogenic granuloma (PG) (8.08%) and peripheral giant cell granuloma (PGCG) (1.68%). The peak incidence of epulis was in the third and fourth decade of life, with a mean age of 45.55 years. Female predominance was found in all types of lesions with a female to male ratio of 1.71:1. PG had the highest recurrence rate (17.18%), followed by POF (12.98%), FFH (9.55%) and PGCG (8.82%). Histological subtypes were significantly correlated with the recurrence of epulis (P = 0.013). Regular supportive periodontal therapy (P = 0.050) had a negative correlation with recurrence, whereas symptoms of periodontitis (P < 0.001) had a positive correlation with the recurrence of epulis.

CONCLUSIONS

Controlling the periodontal inflammation and regular supportive periodontal therapy might help reduce the recurrence of epulis.

摘要

背景

分析不同组织学亚型牙龈瘤的临床病理特征，并评估与复发相关的危险因素。

材料与方法

进行了一项回顾性研究，共纳入 2971 例患者。从患者病历和随访信息中检索患者的性别、年龄、部位、大小、组织学亚型、复发信息、口腔卫生习惯、牙周炎症状和吸烟史。

结果

在 2971 例病例中，局灶性纤维性增生（FFH）最常见（60.92%），其次是外周骨化性纤维瘤（POF）（29.32%）、化脓性肉芽肿（PG）（8.08%）和外周性巨细胞肉芽肿（PGCG）（1.68%）。牙龈瘤的发病高峰在 30 至 40 岁，平均年龄为 45.55 岁。所有类型的病变均以女性为主，男女比例为 1.71:1。PG 的复发率最高（17.18%），其次是 POF（12.98%）、FFH（9.55%）和 PGCG（8.82%）。组织学亚型与牙龈瘤的复发显著相关（P=0.013）。定期支持性牙周治疗（P=0.050）与复发呈负相关，而牙周炎症状（P<0.001）与牙龈瘤的复发呈正相关。