滤泡状和丛状成釉细胞瘤中酪氨酸激酶受体（TrK）的免疫组织化学检测——一项新研究。
Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma - A novel study.
作者信息
Jisha George Babu, Ilayaraja Vadivel, Yoithapprabhunath Thuckanickenpalayam Ragunathan, Ganapathy Nalliappan, Dineshshankar Janardhanam, Nirmal Ramadas Madhavan
机构信息
Consultant Oral and Maxillofacial Pathologist, SM Dental Clinic, Erode, Tamil Nadu, India.
Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women, Namakkal, Tamil Nadu, India.
出版信息
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):125-130. doi: 10.4103/jomfp.JOMFP_220_19. Epub 2020 May 8.
OBJECTIVES
The objective is to analyze the immunohistochemical expression pattern of tyrosine kinase receptor (TrK) in ameloblastoma and to compare the immunohistochemical expression pattern of TrK among the histological types of ameloblastoma, follicular and plexiform patterns.
MATERIALS AND METHODS
Forty ameloblastomas (20 follicular and 20 plexiform) were immunostained with anti-human TrK mouse IgG monoclonal antibody, and the pattern of staining is statistically analyzed.
RESULTS
Total 20 (4 follicular and 16 plexiform) out of 40 ameloblastomas showed immunoreactivity to TrK. Only the peripheral preameloblast like tall columnar cells showed reactivity, whereas the stellate reticulum like cells is immunonegative. The staining pattern was membranous in the immunoreactive cells. The Chi-square value for the immunoexpression between follicular and plexiform ameloblastoma was statistically significant with a < 0.005. The results were studied with the downstream pathways from the literature, and a possible mechanism has been proposed.
CONCLUSION
The expression pattern of TrK is found to be more in plexiform ameloblastoma than follicular ameloblastoma.
目的
分析酪氨酸激酶受体（TrK）在成釉细胞瘤中的免疫组化表达模式，并比较TrK在成釉细胞瘤不同组织学类型（滤泡型和丛状型）中的免疫组化表达模式。
材料与方法
用抗人TrK小鼠IgG单克隆抗体对40例成釉细胞瘤（20例滤泡型和20例丛状型）进行免疫染色，并对染色模式进行统计学分析。
结果
40例成釉细胞瘤中共有20例（4例滤泡型和16例丛状型）对TrK呈免疫反应性。仅周边的成釉器前体细胞样高柱状细胞显示反应性，而星网状细胞样细胞呈免疫阴性。免疫反应性细胞的染色模式为膜性。滤泡型和丛状型成釉细胞瘤之间免疫表达的卡方值具有统计学意义（P<0.005）。结合文献中其下游通路对结果进行了研究，并提出了一种可能的机制。
结论
发现TrK在丛状型成釉细胞瘤中的表达模式比滤泡型成釉细胞瘤更多。
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