Ramani Pratibha, Krishnan Reshma Poothakulath, Karunagaran Monika, Muthusekhar M R
Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):157-163. doi: 10.4103/jomfp.JOMFP_14_20. Epub 2020 May 8.
Ameloblastic fibrosarcoma (AFS) now designated as odontogenic sarcoma is a malignant odontogenic tumor characteristically composed of a benign epithelium and a malignant mesenchymal component. It can arise without any preexisting lesion or it can result from the malignant transformation of ameloblastic fibroma (AF). Hereby, we report an extremely rare case of odontogenic sarcoma which was transformed from AF over a period of about 2 years. This is the first case to be reported after it has been reclassified as odontogenic sarcoma. A systematic review was also done to evaluate the studies that reported AFS arising and AFS arising from AF. The objective of this study is to systematically review the studies that reported AFS arising and AFS arising from AF. Articles that reported AFS arising and AFS arising from AF were collected from PubMed, Medline, Embase, Cochrane, Google search and manual search. The results of the systematic review showed that six studies (46.1%) reported AFS arised with no previous history of AF. Seven studies (53.84%) reported that amelobastic fibrosarcoma arised from AF. A rare case of odontogenic sarcoma transformed from AF is reported here. This is the first case report to be published on odontogenic sarcoma after the World Health Organization reclassification. AF once diagnosed should be treated immediately without any delay to avoid the chances of its malignant transformation into odontogenic sarcoma.
成釉细胞纤维肉瘤（AFS）现被指定为牙源性肉瘤，是一种恶性牙源性肿瘤，其特征是由良性上皮和恶性间充质成分组成。它可以在没有任何先前病变的情况下发生，也可以由成釉细胞纤维瘤（AF）恶变而来。在此，我们报告一例极为罕见的牙源性肉瘤病例，该病例在大约2年的时间里由AF恶变而来。这是在其被重新分类为牙源性肉瘤后报道的首例病例。我们还进行了系统综述，以评估报告的原发性AFS和由AF恶变而来的AFS的研究。本研究的目的是系统综述报告原发性AFS和由AF恶变而来的AFS的研究。从PubMed、Medline、Embase、Cochrane、谷歌搜索和手工检索中收集报告原发性AFS和由AF恶变而来的AFS的文章。系统综述结果显示，六项研究（46.1%）报告的AFS无AF既往史。七项研究（53.84%）报告成釉细胞纤维肉瘤由AF恶变而来。本文报告一例罕见的由AF恶变而来的牙源性肉瘤病例。这是世界卫生组织重新分类后发表的首例牙源性肉瘤病例报告。一旦诊断出AF，应立即进行治疗，不得有任何延误，以避免其恶变为牙源性肉瘤的可能性。
