Salunkhe Vaibhavi, Mahajan Aarti, Prakash Nilima, Pradeep G L, Patil Rekha, Gajdhar Sajda Khan
Department of Oral and Maxillofacial Pathology, MGV's K.B.H. Dental College and Hospital, Nashik, Maharashtra, India.
Department of Oral Pathology and Microbiology, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia.
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):186. doi: 10.4103/jomfp.JOMFP_240_19. Epub 2020 May 8.
Oral squamous cell carcinoma (OSCC) of the head and neck are a heterogeneous group of neoplasms with an increasing rate of mortality and morbidity. OSCCs are characterized by a high degree of local invasiveness and metastasis to cervical lymph nodes but show a lower rate of distant metastasis. Galectin-1 (Gal-1), a β-galactoside-binding lectin, is known to regulate tumor cell growth, angiogenesis, mediate cell-cell or cell-extracellular matrix adhesion and promote cancer cell migration.
This study aims to evaluate the Gal-1 expression in different clinical stages and histological grades of OSCC.
Forty histopathologically diagnosed cases of OSCC, including 16 cases of well-differentiated, 18 moderately differentiated and 6 poorly differentiated carcinomas, were included in the study group.
The samples were subjected to staining using primary mouse monoclonal antibodies against Gal-1 and visualized using polymer-HRP detection system.
The nonparametric Mann-Whitney U-test and Kruskal-Wallis ANOVA test were used for the statistical analysis.
Gal-1 expression was higher in advanced stages of OSCC, and the results were statistically significant. Immunoexpression of Gal-1 increased with advancing histological grades of OSCC with statistically significant results.
Gal-1 plays an important role in invasion, metastasis and as a prognostic marker.
头颈部口腔鳞状细胞癌（OSCC）是一组异质性肿瘤，其死亡率和发病率呈上升趋势。OSCC的特点是具有高度的局部侵袭性和向颈部淋巴结转移，但远处转移率较低。半乳糖凝集素-1（Gal-1）是一种β-半乳糖苷结合凝集素，已知其可调节肿瘤细胞生长、血管生成，介导细胞间或细胞与细胞外基质的黏附，并促进癌细胞迁移。
本研究旨在评估Gal-1在不同临床分期和组织学分级的OSCC中的表达情况。
研究组纳入40例经组织病理学诊断的OSCC病例，其中包括16例高分化癌、18例中分化癌和6例低分化癌。
样本用抗Gal-1的小鼠单克隆抗体进行染色，并使用聚合物-辣根过氧化物酶检测系统进行观察。
采用非参数曼-惠特尼U检验和克鲁斯卡尔-沃利斯方差分析进行统计分析。
Gal-1在OSCC晚期的表达较高，结果具有统计学意义。Gal-1的免疫表达随着OSCC组织学分级的升高而增加，并具有统计学意义。
Gal-1在侵袭、转移中起重要作用，可作为一种预后标志物。
