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胃黏膜相关淋巴组织淋巴瘤患者的二次癌症

Second Cancers in a Patient with Gastric MALT Lymphoma.

作者信息

Navsaria Lucy, Badillo Alfonso, Wang Michael

机构信息

Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Case Rep Med. 2020 May 13;2020:1213596. doi: 10.1155/2020/1213596. eCollection 2020.

DOI:10.1155/2020/1213596
PMID:32508929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7244950/
Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B-cell lymphoma, which is thought to arise from a background of chronic immune stimulation, bacterial, viral, or autoimmune stimuli. Treatment advances have increased the number of MALT lymphoma survivors, but there is still debate as to whether these patients are at a higher risk of developing second cancers. This is a case of a long-surviving (>20 years) patient with multiple diagnosed malignancies following MALT lymphoma. We describe how modern oncological treatment plans can provide patients with prolonged survival and increased quality of life despite increasing age and multiple malignancies.

摘要

黏膜相关淋巴组织(MALT)淋巴瘤是一种结外低度B细胞淋巴瘤,被认为起源于慢性免疫刺激、细菌、病毒或自身免疫刺激的背景。治疗进展增加了MALT淋巴瘤幸存者的数量,但对于这些患者是否有更高的患第二癌症风险仍存在争议。这是一例MALT淋巴瘤后长期存活(>20年)且诊断出多种恶性肿瘤的患者。我们描述了尽管患者年龄增加且患有多种恶性肿瘤,但现代肿瘤治疗方案如何能为患者提供延长的生存期和更高的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/7244950/33b94f28f369/CRIM2020-1213596.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/7244950/33b94f28f369/CRIM2020-1213596.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e37/7244950/33b94f28f369/CRIM2020-1213596.001.jpg

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1
Second Cancers in a Patient with Gastric MALT Lymphoma.胃黏膜相关淋巴组织淋巴瘤患者的二次癌症
Case Rep Med. 2020 May 13;2020:1213596. doi: 10.1155/2020/1213596. eCollection 2020.
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Early cancer of the stomach arising after successful treatment of gastric MALT lymphoma in patients with autoimmune disease.自身免疫性疾病患者胃MALT淋巴瘤成功治疗后发生的早期胃癌。
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Presence of a high-grade component in gastric mucosa-associated lymphoid tissue (MALT) lymphoma is not associated with an adverse prognosis.胃黏膜相关淋巴组织(MALT)淋巴瘤中高级别成分的存在与不良预后无关。
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MALT lymphoma: epidemiology, clinical diagnosis and treatment.黏膜相关淋巴组织淋巴瘤:流行病学、临床诊断与治疗
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Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).
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Risk of second malignancies in patients with gastric marginal zone lymphomas of mucosa associate lymphoid tissue (MALT).黏膜相关淋巴组织(MALT)型胃边缘区淋巴瘤患者发生第二原发性恶性肿瘤的风险
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Genomic analysis of non-splenic marginal zone lymphomas (MZL) indicates similarities between nodal and extranodal MZL and supports their derivation from memory B-cells.对非脾脏边缘区淋巴瘤(MZL)的基因组分析表明,结内和结外 MZL 之间存在相似性,并支持它们来源于记忆 B 细胞。
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EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT.EGILS 共识报告。胃黏膜相关边缘区 B 细胞淋巴瘤。
Gut. 2011 Jun;60(6):747-58. doi: 10.1136/gut.2010.224949. Epub 2011 Feb 11.
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Risk for second malignancies in non-Hodgkin's lymphoma survivors: a meta-analysis.非霍奇金淋巴瘤幸存者的二次恶性肿瘤风险:一项荟萃分析。
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