Xu Linfeng, Wang Anyang, Li Xiangpeng, Oh Kwang W
Department of Bioengineering and Therapeutic Sciences, Schools of Medicine and Pharmacy, University of California San Francisco, 1700 4th Street, Byers Hall 304, San Francisco, California 94158, USA.
SMALL (Sensors and MicroActuators Learning Lab), Department of Electrical Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
Biomicrofluidics. 2020 May 27;14(3):031503. doi: 10.1063/5.0002169. eCollection 2020 May.
Suitable micropumping methods for flow control represent a major technical hurdle in the development of microfluidic systems for point-of-care testing (POCT). Passive micropumping for point-of-care microfluidic systems provides a promising solution to such challenges, in particular, passive micropumping based on capillary force and air transfer based on the air solubility and air permeability of specific materials. There have been numerous developments and applications of micropumping techniques that are relevant to the use in POCT. Compared with active pumping methods such as syringe pumps or pressure pumps, where the flow rate can be well-tuned independent of the design of the microfluidic devices or the property of the liquids, most passive micropumping methods still suffer flow-control problems. For example, the flow rate may be set once the device has been made, and the properties of liquids may affect the flow rate. However, the advantages of passive micropumping, which include simplicity, ease of use, and low cost, make it the best choice for POCT. Here, we present a systematic review of different types of passive micropumping that are suitable for POCT, alongside existing applications based on passive micropumping. Future trends in passive micropumping are also discussed.
适用于流量控制的微泵技术是即时检测（POCT）微流控系统开发中的一个主要技术障碍。用于即时检测微流控系统的被动式微泵为这类挑战提供了一个有前景的解决方案，特别是基于毛细作用力的被动式微泵以及基于特定材料的空气溶解性和透气性的空气传输方式。与即时检测应用相关的微泵技术已有众多进展和应用。与诸如注射泵或压力泵等主动式泵浦方法相比，主动式泵浦方法的流速可以在不考虑微流控装置设计或液体性质的情况下进行良好调节，而大多数被动式微泵方法仍然存在流量控制问题。例如，一旦装置制造完成，流速可能就已设定，并且液体的性质可能会影响流速。然而，被动式微泵的优点，包括简单、易用和低成本，使其成为即时检测的最佳选择。在此，我们对适用于即时检测的不同类型被动式微泵以及基于被动式微泵的现有应用进行了系统综述。还讨论了被动式微泵的未来发展趋势。
