Research Laboratory of Biophysics, National University of Science and Technology «MISiS», 119049 Moscow, Russia.
Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
Biosensors (Basel). 2022 Nov 1;12(11):956. doi: 10.3390/bios12110956.
This review is an account of methods that use various strategies to control microfluidic flow control with high accuracy. The reviewed systems are divided into two large groups based on the way they create flow: passive systems (non-mechanical systems) and active (mechanical) systems. Each group is presented by a number of device fabrications. We try to explain the main principles of operation, and we list advantages and disadvantages of the presented systems. Mechanical systems are considered in more detail, as they are currently an area of increased interest due to their unique precision flow control and "multitasking". These systems are often applied as mini-laboratories, working autonomously without any additional operations, provided by humans, which is very important under complicated conditions. We also reviewed the integration of autonomous microfluidic systems with a smartphone or single-board computer when all data are retrieved and processed without using a personal computer. In addition, we discuss future trends and possible solutions for further development of this area of technology.
这篇综述是对使用各种策略来实现高精度微流控流量控制的方法的描述。所综述的系统根据其产生流动的方式分为两组：被动系统（非机械系统）和主动（机械）系统。每个组都由一些器件制造方法组成。我们尝试解释主要的工作原理，并列出了所提出系统的优缺点。由于其独特的精密流量控制和“多功能性”，机械系统被更详细地考虑，因为它们目前是一个日益受到关注的领域。这些系统通常作为微型实验室应用，无需任何额外的人类操作即可自主工作，这在复杂条件下非常重要。我们还回顾了自主微流控系统与智能手机或单板计算机的集成，在这种情况下，所有数据都无需使用个人计算机即可检索和处理。此外，我们还讨论了该技术领域未来的发展趋势和可能的解决方案。
