• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Hypoxia promotes proliferation of pituitary adenomas by HIF-1α/ALKBH5 signaling .缺氧通过HIF-1α/ALKBH5信号通路促进垂体腺瘤增殖。
Int J Clin Exp Pathol. 2020 May 1;13(5):1030-1034. eCollection 2020.
2
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.缺氧通过HIF依赖和ALKBH5介导的NANOG mRNA的m⁶A去甲基化诱导乳腺癌干细胞表型。
Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2047-56. doi: 10.1073/pnas.1602883113. Epub 2016 Mar 21.
3
Hypoxia induces hemorrhagic transformation in pituitary adenomas via the HIF-1α signaling pathway.缺氧通过 HIF-1α 信号通路诱导垂体腺瘤发生出血性转化。
Oncol Rep. 2011 Dec;26(6):1457-64. doi: 10.3892/or.2011.1416. Epub 2011 Aug 5.
4
Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells.缺氧诱导因子-1α对阿特T-20细胞中地塞米松诱导的凋亡抑制和糖皮质激素受体下调的影响。
BMC Endocr Disord. 2015 May 23;15:24. doi: 10.1186/s12902-015-0017-2.
5
[Hypoxia/reoxygenation and lipopolysaccharide induced nuclear factor-ΚB and hypoxia-inducible factor-1α signaling pathways in intestinal epithelial cell injury and the interventional effect of emodin].[缺氧/复氧及脂多糖诱导核因子-κB和缺氧诱导因子-1α信号通路在肠上皮细胞损伤中的作用及大黄素的干预效应]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Jun;26(6):409-14. doi: 10.3760/cma.j.issn.2095-4352.2014.06.009.
6
[Effects of hypoxia inducible factor-1α on P311 and its influence on the migration of murine epidermal stem cells].缺氧诱导因子-1α对P311的影响及其对小鼠表皮干细胞迁移的作用
Zhonghua Shao Shang Za Zhi. 2017 May 20;33(5):287-294. doi: 10.3760/cma.j.issn.1009-2587.2017.05.007.
7
Role of hypoxia-inducible factor-1 alpha in the regulation of plasminogen activator activity in rat knee joint chondrocytes.缺氧诱导因子-1α在大鼠膝关节软骨细胞中纤溶酶原激活物活性调节中的作用。
Osteoarthritis Cartilage. 2009 Nov;17(11):1494-502. doi: 10.1016/j.joca.2009.05.005. Epub 2009 May 19.
8
[Impact of RNA interference targeting hypoxia-inducible factor-1alpha on chemosensitivity in esophageal squamous cell carcinoma cells under hypoxia].[RNA干扰靶向缺氧诱导因子-1α对缺氧条件下食管鳞状细胞癌细胞化疗敏感性的影响]
Zhonghua Yi Xue Za Zhi. 2007 Oct 9;87(37):2640-4.
9
Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway.缺氧诱导因子-1α（HIF-1α）基因敲低抑制体外缺氧条件下外根鞘细胞的增殖和迁移：与音猬因子（Shh）信号通路有关
Life Sci. 2017 Dec 15;191:82-89. doi: 10.1016/j.lfs.2017.10.011. Epub 2017 Oct 10.
10
Expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in pituitary adenomas.缺氧诱导因子1α和血管内皮生长因子在垂体腺瘤中的表达
Endocr Pathol. 2005 Summer;16(2):115-21. doi: 10.1385/ep:16:2:115.

引用本文的文献

1
Air Pollution and Pituitary Adenoma Pathogenesis: Unraveling Environmental Impacts on Neuroendocrine Function and Tumorigenesis.空气污染与垂体腺瘤发病机制：揭示环境对神经内分泌功能及肿瘤发生的影响
J Xenobiot. 2025 May 12;15(3):71. doi: 10.3390/jox15030071.
2
A systematic review of molecular alterations in invasive non-functioning pituitary adenoma.侵袭性无功能垂体腺瘤分子改变的系统评价
Endocrine. 2022 Sep;77(3):500-509. doi: 10.1007/s12020-022-03105-9. Epub 2022 Jun 16.
3
RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential.RNA 去甲基酶 ALKBH5 在癌症中的作用：从机制到治疗潜力。
J Hematol Oncol. 2022 Jan 21;15(1):8. doi: 10.1186/s13045-022-01224-4.

本文引用的文献

1
Functions of N6-methyladenosine and its role in cancer.N6-甲基腺苷的功能及其在癌症中的作用。
Mol Cancer. 2019 Dec 4;18(1):176. doi: 10.1186/s12943-019-1109-9.
2
Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance.实体瘤中的缺氧：癌症干细胞（CSC）耐药性的关键促进因素。
J Cancer Res Clin Oncol. 2020 Jan;146(1):19-31. doi: 10.1007/s00432-019-03080-1. Epub 2019 Nov 16.
3
Functions of RNA N6-methyladenosine modification in cancer progression.RNA N6-甲基腺苷修饰在癌症进展中的作用。
Mol Biol Rep. 2019 Apr;46(2):2567-2575. doi: 10.1007/s11033-019-04655-4. Epub 2019 Mar 25.
4
Nanog Signaling Mediates Radioresistance in ALDH-Positive Breast Cancer Cells.Nanog 信号转导介导 ALDH 阳性乳腺癌细胞的放射抵抗。
Int J Mol Sci. 2019 Mar 6;20(5):1151. doi: 10.3390/ijms20051151.
5
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2.核 FGFR2 通过与 HIF-1 和 HIF-2 相互作用负调控前列腺癌细胞缺氧诱导的侵袭。
Sci Rep. 2019 Mar 5;9(1):3480. doi: 10.1038/s41598-019-39843-6.
6
New insight into NANOG: A novel therapeutic target for ovarian cancer (OC).对 NANOG 的新认识：卵巢癌 (OC) 的新治疗靶点。
Eur J Pharmacol. 2019 Jun 5;852:51-57. doi: 10.1016/j.ejphar.2019.03.003. Epub 2019 Mar 2.
7
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015.CBTRUS统计报告：2011 - 2015年美国原发性脑肿瘤及其他中枢神经系统肿瘤诊断情况
Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86. doi: 10.1093/neuonc/noy131.
8
Role of HIF-1 in Cancer Progression: Novel Insights. A Review.缺氧诱导因子-1在癌症进展中的作用：新见解。综述。
Curr Mol Med. 2018;18(6):343-351. doi: 10.2174/1566524018666181109121849.
9
Prognostic and clinicopathological value of Nanog in hepatocellular carcinoma: A meta-analysis.Nanog 在肝细胞癌中的预后及临床病理价值：一项荟萃分析。
Clin Chim Acta. 2018 Feb;477:24-31. doi: 10.1016/j.cca.2017.11.037. Epub 2017 Dec 2.
10
NANOG as an adverse predictive marker in advanced non-small cell lung cancer treated with platinum-based chemotherapy.NANOG作为接受铂类化疗的晚期非小细胞肺癌的不良预测标志物。
Onco Targets Ther. 2017 Sep 19;10:4625-4633. doi: 10.2147/OTT.S144895. eCollection 2017.

缺氧通过HIF-1α/ALKBH5信号通路促进垂体腺瘤增殖。

Hypoxia promotes proliferation of pituitary adenomas by HIF-1α/ALKBH5 signaling .

作者信息

Qian Yuan, Zhang Chao, Wang Wei, Lu Di, Li Junjun, Li Liyan, Li Yao, Qiao Yisheng, Song Hao, Deng Xingli

机构信息

Yunnan Key Laboratory of Laboratory Medicine, 1st Affiliated Hospital of Kunming Medical University Kunming, China.

Department of Medical Genetics and Prenatal Diagnosis, Kunming Maternal and Child Health Hospital Kunming, China.

出版信息

Int J Clin Exp Pathol. 2020 May 1;13(5):1030-1034. eCollection 2020.

PMID:32509075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7270662/
Abstract

Hypoxia is a common phenomenon in pituitary adenomas (PAs). The role and mechanism of hypoxia in the PAs remains elusive. This work aimed to explore the effect of hypoxia on PAs in vitro. PA cells GT1-1 were cultured and treated under hypoxic condition. Cell proliferation assay showed the proliferation of PA cells was increased significantly by hypoxia treatment, with a peak at 12 hours. qPCR and western blot indicated that the expression of HIF-1α, ALKBH5, and Nanog were elevated by hypoxia stimuli. In conclusion, our funding demonstrated that hypoxia could increase Nanog expression through HIF-1α/ALKBH5 signaling, thereby promoting the proliferation of PA cells.

摘要

缺氧是垂体腺瘤（PA）中的常见现象。缺氧在PA中的作用和机制仍不清楚。这项工作旨在探讨缺氧对体外PA的影响。将PA细胞GT1-1在缺氧条件下进行培养和处理。细胞增殖试验表明，缺氧处理显著增加了PA细胞的增殖，在12小时达到峰值。定量聚合酶链反应（qPCR）和蛋白质免疫印迹法（western blot）表明，缺氧刺激使缺氧诱导因子-1α（HIF-1α）、RNA去甲基化酶5（ALKBH5）和Nanog的表达升高。总之，我们的研究表明，缺氧可通过HIF-1α/ALKBH5信号通路增加Nanog表达，从而促进PA细胞的增殖。