Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
J Cancer Res Clin Oncol. 2020 Jan;146(1):19-31. doi: 10.1007/s00432-019-03080-1. Epub 2019 Nov 16.
Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and are endowed with self-renewal and resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC resistance and targeting for effective cancer therapy.
Preferential localization within hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification of responses to various stressors and, as a result, show a more aggressive behavior.
Hypoxia, in fact, serves as a multi-tasking strategy to nurture CSCs with this adaptive capacity, complexing targeted therapies.
癌症干细胞（CSCs）是高度致瘤性的细胞类型，存在于肿瘤微环境（TME）的特定区域，并具有自我更新和抵抗特性。在这里，我们旨在讨论缺氧衍生的 CSC 抵抗机制及其作为有效癌症治疗的靶点。
在缺氧生态位中的优先定位将有助于 CSCs 发展适应机制，通过对各种应激源的反应的修饰来介导，并且结果表现出更具侵略性的行为。
事实上，缺氧作为一种多任务策略，为具有这种适应能力的 CSCs 提供营养，使靶向治疗复杂化。
