Akiyama Y, Hara K, Kato Y, Takizawa K, Sato M, Tajima T
Department of Pharmacology, Tokyo Research Laboratories, Eisai Co., Ltd., Japan.
Nihon Yakurigaku Zasshi. 1988 Dec;92(6):381-7. doi: 10.1254/fpj.92.381.
The influence of aztreonam (AZT), a new monobactam antibiotic, on blood coagulation was compared with latamoxef (LMOX), cefoperazon (CPZ), cefotetan (CTT) and ampicillin (ABPC). These antibiotics were administered intraperitoneally once a day for 7 days to rats fed a vitamin K-deficient diet. On the 8th day, blood coagulation activity and bacteria in the caecum were observed. 1) One hundred mg/kg and 300 mg/kg of LMOX prolonged the blood coagulation time and decreased normal prothrombin in a dose-dependent manner. CPZ, CTT and ABPC (300 mg/kg each) decreased both of these parameters, but not as much as LMOX did. AZT (300 mg/kg) had no effect on these parameters. 2) Three hundred mg/kg of ABPC and LMOX decreased the viable cell counts of all aerobic G (+), aerobic G (-), and anaerobic bacteria and yeast, while AZT decreased only aerobic G (-) bacteria. These results suggest that AZT may be less likely to induce hypoprothrombinemia than other antibiotics in clinical use.
将新型单环β-内酰胺类抗生素氨曲南（AZT）对血液凝固的影响与拉氧头孢（LMOX）、头孢哌酮（CPZ）、头孢替坦（CTT）和氨苄西林（ABPC）进行了比较。将这些抗生素每天腹腔注射一次，连续7天给予饲喂维生素K缺乏饮食的大鼠。在第8天，观察血液凝固活性和盲肠中的细菌。1）100mg/kg和300mg/kg的LMOX以剂量依赖的方式延长了血液凝固时间并降低了正常凝血酶原。CPZ、CTT和ABPC（各300mg/kg）降低了这两个参数，但程度不如LMOX。AZT（300mg/kg）对这些参数没有影响。2）300mg/kg的ABPC和LMOX降低了所有需氧G（+）、需氧G（-）、厌氧细菌和酵母菌的活菌计数，而AZT仅降低了需氧G（-）细菌。这些结果表明，在临床应用中，AZT诱导低凝血酶原血症的可能性可能低于其他抗生素。
