Wang Huiyu, Zhou Chunli, Huang Junxiang, Kuai Xiaoyi, Shao Xinyu
Department of Gastroenterology, The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou, Jiangsu, China.
Am J Transl Res. 2020 May 15;12(5):1569-1583. eCollection 2020.
Inflammatory bowel disease (IBD) is a chronic intestinal disease of unknown etiology. However, recent studies have established a pathological role of disordered intestinal microbiota and immune dysregulation. Clinical studies have suggested that the reconstruction of the normal intestinal flora in patients with IBD can reverse the dysbiosis caused by genetic, environmental, dietary, or antibiotic factors to ameliorate the symptoms of IBD. is widely present in the intestines of healthy individuals and regulates the intestinal immune system, reducing inflammation through multiple mechanisms. This review summarizes the current knowledge of the role of in maintaining intestinal homeostasis and considers its possible value as a new therapeutic agent for patients with IBD.
炎症性肠病(IBD)是一种病因不明的慢性肠道疾病。然而,最近的研究已经证实肠道微生物群紊乱和免疫失调在其病理过程中发挥作用。临床研究表明,重建IBD患者的正常肠道菌群可以逆转由遗传、环境、饮食或抗生素因素引起的生态失调,从而改善IBD的症状。 广泛存在于健康个体的肠道中,并调节肠道免疫系统,通过多种机制减轻炎症。本综述总结了目前关于 在维持肠道稳态中作用的认识,并探讨了其作为IBD患者新型治疗药物的潜在价值。