Coppée F, Lechien J R, Declèves A-E, Tafforeau L, Saussez S
Department of Metabolic and Molecular Biochemistry, Research Institute for Health Sciences and Technology, University of Mons, Belgium.
Department of Human Anatomy and Experimental Oncology, Research Institute for Health Sciences and Technology, University of Mons, Belgium.
New Microbes New Infect. 2020 Jul;36:100696. doi: 10.1016/j.nmni.2020.100696. Epub 2020 May 20.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is being intensively studied, particularly its evolution, in the increasingly available sequences between countries/continents with classical phylogenetic tree representation. More recently, certain protein mutations have been correlated with specific functional impacts. Our clinical data from patients suggest that clinical symptoms differ between European countries. Among other factors, SARS-CoV-2 mutations could explain these disparities. Our analyses point to an association of diverse mutations, including co-evolving ones, in a few SARS-CoV-2 proteins within specific countries. We therefore suggest combining clinical information from patients and the determination of the associated SARS-CoV-2 genome to better understand the specific symptoms.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）正在被深入研究，尤其是其进化情况，研究采用经典系统发育树表示法，基于国家/各大洲间日益丰富的序列展开。最近，某些蛋白质突变已与特定的功能影响相关联。我们来自患者的临床数据表明，欧洲国家之间的临床症状存在差异。除其他因素外，SARS-CoV-2突变可能解释这些差异。我们的分析指出，在特定国家内，几种SARS-CoV-2蛋白中存在多种突变的关联，包括共同进化的突变。因此，我们建议将患者的临床信息与相关SARS-CoV-2基因组的测定相结合，以更好地了解具体症状。
