Franzone J S, Cravanzola C, Reboani M C, Torrielli M V, Pernigotti M L
ABC S.p.A. Research Laboratories, Turin, Italy.
Int J Tissue React. 1988;10(4):233-43.
The inhibitory effect of elastase on experimental atherosclerosis has been reported in numerous studies. In our investigation, performed in the rat, a pancreatic extract provided with elastolytic activity has been shown to possess an anti-aggregative effect in vitro and ex vivo and anti-thrombotic properties. In addition, the elastase was capable of inhibiting endothelial exfoliation induced by the desquamatory agent sodium citrate. This agent was tested for its microhaemorrhoeological activity in acute and subacute experiments. In both these conditions, elastase was able to increase the flexibility of red blood cells and their resistance to lysis provoked by hypotonic solutions. In animals fed on an atherogenic diet, this substance limited the lipoprotein accumulation in the aorta wall. Moreover, it reduced the enhanced calcium content, induced by vitamin D administration, in the tissue of arteries. These data indicate that elastase can counteract some pathobiological aspects that characterize atherosclerotic events.
众多研究已报道了弹性蛋白酶对实验性动脉粥样硬化的抑制作用。在我们以大鼠进行的研究中，一种具有弹性蛋白分解活性的胰腺提取物已被证明在体外和体内均具有抗聚集作用及抗血栓形成特性。此外，弹性蛋白酶能够抑制由脱屑剂柠檬酸钠诱导的内皮剥脱。在急性和亚急性实验中对该试剂的微血液流变学活性进行了测试。在这两种情况下，弹性蛋白酶都能够增加红细胞的柔韧性及其对低渗溶液诱导的溶血的抵抗力。在喂食致动脉粥样硬化饮食的动物中，这种物质限制了主动脉壁中脂蛋白的积累。此外，它降低了维生素D给药诱导的动脉组织中钙含量的增加。这些数据表明弹性蛋白酶可以抵消动脉粥样硬化事件所特有的一些病理生物学方面的影响。
