Jamalian Mohammad, Mahmodiyeh Behnam, Saveiee Sahar, Solhi Hasan
Department of Forensic Medicine and Poisoning, Arak University of Medical Sciences, Arak, Iran.
Department of Anesthesiology and Critical Care, Arak University of Medical Sciences, Arak, Iran.
J Family Med Prim Care. 2020 Mar 26;9(3):1707-1711. doi: 10.4103/jfmpc.jfmpc_929_19. eCollection 2020 Mar.
Various drugs affect liver problems caused by general hypoxia, including silymarin. Due to the fungal killer toxins, nowadays, silymarin (milk thistle) is used as an effective drug in the prevention and treatment of liver diseases and liver toxicity. In addition, silymarin protects the liver cells from solvents and chemical substances. The aim of this paper is to investigate the impact of silymarin on liver problems induced by general hypoxia.
This study was a double-blinded clinical trial on patients with hypoxia who referred to the hospital emergency department. Patients were randomly divided into case and control groups. The case group was treated with silymarin at a dose of 280 mg with orally gavage technique and the control group was treated with a placebo every 8 h for 3 days. To investigate the leukocytosis, liver enzymes levels of alanine transaminase (ALT), aspartate aminotransferase (AST), creatine phosphokinase (CPK), prothrombin time (PT), partial thromboplastin (PTT), international normalized ratio (INR), and white blood cell (WBC) were measured before and after the intervention. SPSS 21 software was used to analyze the data.
In the silymarin group, liver enzymes were lower than the placebo group on the third day after treatment ( < 0.05). There was no significant difference between the two groups in terms of coagulation factors and WBC count on the third day after treatment ( > 050). On the third day after treatment, the amount of GGT was lower in the silymarin group ( < 0.05).
Silymarin decreased liver enzymes (ALT, AST, and CPK) and the level of GGT. Therefore, it is recommended to be used in patients with hypoxic liver injury.
多种药物可影响由全身性缺氧引起的肝脏问题，包括水飞蓟素。由于真菌杀伤毒素，如今水飞蓟素（奶蓟）被用作预防和治疗肝脏疾病及肝毒性的有效药物。此外，水飞蓟素可保护肝细胞免受溶剂和化学物质的侵害。本文旨在研究水飞蓟素对全身性缺氧所致肝脏问题的影响。
本研究是一项针对转诊至医院急诊科的缺氧患者的双盲临床试验。患者被随机分为病例组和对照组。病例组采用口服灌胃技术给予剂量为280毫克的水飞蓟素治疗，对照组每8小时给予安慰剂治疗，持续3天。为研究白细胞增多情况，在干预前后测量丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、肌酸磷酸激酶（CPK）、凝血酶原时间（PT）、部分凝血活酶时间（PTT）、国际标准化比值（INR）和白细胞（WBC）的肝酶水平。使用SPSS 21软件分析数据。
在水飞蓟素组，治疗后第三天肝酶低于安慰剂组（<0.05）。治疗后第三天，两组在凝血因子和白细胞计数方面无显著差异（>0.05）。治疗后第三天，水飞蓟素组的γ-谷氨酰转移酶（GGT）水平较低（<0.05）。
水飞蓟素可降低肝酶（ALT、AST和CPK）及GGT水平。因此，建议用于缺氧性肝损伤患者。
