Roffel Mirjam P, Bracke Ken R, Heijink Irene H, Maes Tania
Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent University, Ghent, Belgium.
Departments of Pathology and Medical Biology and Pulmonology, Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Front Med (Lausanne). 2020 May 19;7:196. doi: 10.3389/fmed.2020.00196. eCollection 2020.
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive respiratory diseases characterized by airway obstruction, inflammation, and remodeling. Recent findings indicate the importance of microRNAs (miRNAs) in the regulation of pathological processes involved in both diseases. MiRNAs have been implicated in a wide array of biological processes, such as inflammation, cell proliferation, differentiation, and death. MiR-223 is one of the miRNAs that is thought to play a role in obstructive lung disease as altered expression levels have been observed in both asthma and COPD. MiR-223 is a hematopoietic cell-derived miRNA that plays a role in regulation of monocyte-macrophage differentiation, neutrophil recruitment, and pro-inflammatory responses and that can be transferred to non-myeloid cells via extracellular vesicles or lipoproteins. In this translational review, we highlight the role of miR-223 in obstructive respiratory diseases, focusing on expression data in clinical samples of asthma and COPD, experiments in mouse models and functional studies. Furthermore, we provide an overview of the mechanisms by which miR-223 regulates gene expression. We specifically focus on immune cell development and activation and involvement in immune responses, which are important in asthma and COPD. Collectively, this review demonstrates the importance of miR-223 in obstructive respiratory diseases and explores its therapeutic potential in the pathogenesis of asthma and COPD.
哮喘和慢性阻塞性肺疾病（COPD）是慢性阻塞性呼吸道疾病，其特征为气道阻塞、炎症和重塑。最近的研究结果表明，微小RNA（miRNA）在这两种疾病所涉及的病理过程调控中具有重要作用。miRNA参与了广泛的生物学过程，如炎症、细胞增殖、分化和死亡。MiR-223是被认为在阻塞性肺病中发挥作用的miRNA之一，因为在哮喘和COPD中均观察到其表达水平发生了改变。MiR-223是一种造血细胞衍生的miRNA，在单核细胞-巨噬细胞分化、中性粒细胞募集和促炎反应的调控中发挥作用，并且可以通过细胞外囊泡或脂蛋白转移至非髓系细胞。在这篇转化医学综述中，我们重点介绍了MiR-223在阻塞性呼吸道疾病中的作用，重点关注哮喘和COPD临床样本中的表达数据、小鼠模型实验和功能研究。此外，我们概述了MiR-223调控基因表达的机制。我们特别关注免疫细胞的发育和激活以及在免疫反应中的参与情况，这在哮喘和COPD中都很重要。总体而言，这篇综述证明了MiR-223在阻塞性呼吸道疾病中的重要性，并探讨了其在哮喘和COPD发病机制中的治疗潜力。
