• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

细胞因子通过 Notch 信号诱导猴神经干细胞分化。

Cytokines Induce Monkey Neural Stem Cell Differentiation through Notch Signaling.

机构信息

National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Department of Neurobiology, Shanxi Medical University, Taiyuan 030001, China.

College of Medicine, Jiaxing University, Jiaxing 314001, China.

出版信息

Biomed Res Int. 2020 May 13;2020:1308526. doi: 10.1155/2020/1308526. eCollection 2020.

DOI:10.1155/2020/1308526
PMID:32509845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7244951/
Abstract

The mammalian central nervous system (CNS) has a limited ability to renew the damaged cells after a brain or spinal cord injury whether it is nonhuman primates like monkeys or humans. Transplantation of neural stem cells (NSCs) is a potential therapy for CNS injuries due to their pluripotency and differentiation abilities. Cytokines play an important role in CNS development and repair of CNS injuries. However, the detailed cytokine signaling response in monkey neural stem cells is rarely studied. In our previous research, we isolated NSCs from the adult monkey brain and found the effects of cytokines on monkey NSCs. Now, we further analyzed the regulation mechanisms of cytokines to the proliferation of monkey NSCs such as bone morphogenic protein 4 (BMP4), BMP4/leukaemia inhibitory factor (LIF), or retinoic acid (RA)/Forskolin. The data showed that BMP4 inhibited cell proliferation to arrest, but it did not affect the stemness of NSCs. BMP4/LIF promoted the astrocyte-like differentiation of monkey NSCs, and RA/forskolin induced the neuronal differentiation of monkey NSCs. BMP4/LIF and RA/forskolin induced monkey NSC differentiation by regulating Notch signaling. These results provide some theoretical evidence for NSC therapy to brain or spinal cord injury in regenerative medicine.

摘要

哺乳动物中枢神经系统（CNS）在脑或脊髓损伤后，无论是在非人类灵长类动物（如猴子）还是人类中，都只有有限的能力来更新受损细胞。神经干细胞（NSCs）的移植是一种潜在的 CNS 损伤治疗方法，因为它们具有多能性和分化能力。细胞因子在 CNS 发育和 CNS 损伤修复中发挥重要作用。然而，猴子神经干细胞中细胞因子信号转导的详细反应很少被研究。在我们之前的研究中，我们从成年猴子大脑中分离出 NSCs，并发现细胞因子对猴子 NSCs 的影响。现在，我们进一步分析了细胞因子对猴子 NSCs 增殖的调节机制，如骨形态发生蛋白 4（BMP4）、BMP4/白血病抑制因子（LIF）或视黄酸（RA）/佛司可林。数据表明，BMP4 抑制细胞增殖以阻止其分裂，但不影响 NSCs 的干性。BMP4/LIF 促进猴子 NSCs 的星形胶质细胞样分化，而 RA/forskolin 诱导猴子 NSCs 的神经元分化。BMP4/LIF 和 RA/forskolin 通过调节 Notch 信号诱导猴子 NSC 分化。这些结果为再生医学中 NSC 治疗脑或脊髓损伤提供了一些理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/a9202b0bd0c9/BMRI2020-1308526.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/4e10c4a5961e/BMRI2020-1308526.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/64fa82d952cf/BMRI2020-1308526.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/c06146225a8d/BMRI2020-1308526.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/ccfcb2295226/BMRI2020-1308526.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/2886c7731951/BMRI2020-1308526.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/a9202b0bd0c9/BMRI2020-1308526.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/4e10c4a5961e/BMRI2020-1308526.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/64fa82d952cf/BMRI2020-1308526.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/c06146225a8d/BMRI2020-1308526.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/ccfcb2295226/BMRI2020-1308526.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/2886c7731951/BMRI2020-1308526.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5599/7244951/a9202b0bd0c9/BMRI2020-1308526.006.jpg

相似文献

1
Cytokines Induce Monkey Neural Stem Cell Differentiation through Notch Signaling.细胞因子通过 Notch 信号诱导猴神经干细胞分化。
Biomed Res Int. 2020 May 13;2020:1308526. doi: 10.1155/2020/1308526. eCollection 2020.
2
BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain.骨形态发生蛋白4/白血病抑制因子或视黄酸/福斯高林抑制成年猴脑源性神经干细胞的增殖。
Stem Cells Int. 2017;2017:7012405. doi: 10.1155/2017/7012405. Epub 2017 Sep 20.
3
Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair.免疫药理学干预在神经干细胞治疗中的成功应用：中枢神经系统神经发生和修复的新视角。
Pharmacol Ther. 2014 Jan;141(1):21-31. doi: 10.1016/j.pharmthera.2013.08.001. Epub 2013 Aug 15.
4
NOTCH Signaling Is Essential for Maturation, Self-Renewal, and Tri-Differentiation of In Vitro Derived Human Neural Stem Cells.NOTCH信号通路对于体外诱导的人神经干细胞的成熟、自我更新和三向分化至关重要。
Cell Reprogram. 2017 Dec;19(6):372-383. doi: 10.1089/cell.2017.0009. Epub 2017 Oct 16.
5
Combined use of bFGF/EGF and all-trans-retinoic acid cooperatively promotes neuronal differentiation and neurite outgrowth in neural stem cells.碱性成纤维细胞生长因子/表皮生长因子与全反式维甲酸联合使用可协同促进神经干细胞的神经元分化和神经突生长。
Neurosci Lett. 2019 Jan 18;690:61-68. doi: 10.1016/j.neulet.2018.10.002. Epub 2018 Oct 6.
6
Effect of spinal cord extracts after spinal cord injury on proliferation of rat embryonic neural stem cells and Notch signal pathway in vitro.脊髓损伤后脊髓提取物对大鼠胚胎神经干细胞增殖及体外Notch信号通路的影响
Asian Pac J Trop Med. 2014 Jul;7(7):562-7. doi: 10.1016/S1995-7645(14)60094-8.
7
A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal.神经干细胞中具有促生长信号作用的细胞周期蛋白 D1 具有抗星形胶质发生功能，以执行自我更新。
Stem Cells. 2014 Jun;32(6):1602-15. doi: 10.1002/stem.1613.
8
Deficiency of Ttyh1 downstream to Notch signaling results in precocious differentiation of neural stem cells.Notch 信号下游的 Ttyh1 缺乏导致神经干细胞过早分化。
Biochem Biophys Res Commun. 2019 Jun 30;514(3):842-847. doi: 10.1016/j.bbrc.2019.04.181. Epub 2019 May 10.
9
Retinoic acid induced the differentiation of neural stem cells from embryonic spinal cord into functional neurons in vitro.维甲酸在体外诱导胚胎脊髓神经干细胞分化为功能性神经元。
Int J Clin Exp Pathol. 2015 Jul 1;8(7):8129-35. eCollection 2015.
10
A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice.一种新型 2-苯氨基喹唑啉类化合物可扩增神经干细胞池，促进成年小鼠海马神经发生和认知能力。
Stem Cells. 2018 Aug;36(8):1273-1285. doi: 10.1002/stem.2843. Epub 2018 May 12.

引用本文的文献

1
Sodium tanshinone IIA sulfonate promotes proliferation and differentiation of endogenous neural stem cells to repair rat spinal cord injury via the Notch pathway.丹参酮IIA磺酸钠通过Notch通路促进内源性神经干细胞增殖和分化以修复大鼠脊髓损伤。
J Transl Med. 2025 Mar 24;23(1):367. doi: 10.1186/s12967-025-06331-7.
2
Noggin-Loaded PLA/PCL Patch Inhibits BMP-Initiated Reactive Astrogliosis.载有 Noggin 的 PLA/PCL 贴片抑制 BMP 引发的反应性星形胶质细胞增生。
Int J Mol Sci. 2024 Oct 29;25(21):11626. doi: 10.3390/ijms252111626.
3
The Implications of Cannabinoid-Induced Metabolic Dysregulation for Cellular Differentiation and Growth.

本文引用的文献

1
The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.Nanog 诱导小鼠胚胎干细胞自我更新的分子逻辑。
Nat Commun. 2019 Mar 7;10(1):1109. doi: 10.1038/s41467-019-09041-z.
2
Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology.Noggin 可挽救具有神经退行性病理的衰老小鼠大脑中的与年龄相关的干细胞损失。
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11625-11630. doi: 10.1073/pnas.1813205115. Epub 2018 Oct 23.
3
Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications.
大麻素诱导的代谢失调对细胞分化和生长的影响。
Int J Mol Sci. 2023 Jul 2;24(13):11003. doi: 10.3390/ijms241311003.
4
Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases.白血病抑制因子，人类疾病治疗中具有双刃剑效应的分子。
Mol Ther. 2023 Feb 1;31(2):331-343. doi: 10.1016/j.ymthe.2022.12.016. Epub 2022 Dec 26.
5
A Tale of Two: When Neural Stem Cells Encounter Hypoxia.双雄对决：神经干细胞遭遇缺氧。
Cell Mol Neurobiol. 2023 Jul;43(5):1799-1816. doi: 10.1007/s10571-022-01293-6. Epub 2022 Oct 29.
6
The roles and applications of neural stem cells in spinal cord injury repair.神经干细胞在脊髓损伤修复中的作用及应用
Front Bioeng Biotechnol. 2022 Aug 29;10:966866. doi: 10.3389/fbioe.2022.966866. eCollection 2022.
7
Neural stem cell therapy for brain disease.用于脑部疾病的神经干细胞疗法。
World J Stem Cells. 2021 Sep 26;13(9):1278-1292. doi: 10.4252/wjsc.v13.i9.1278.
8
Targeting Liver Cancer Stem Cells: An Alternative Therapeutic Approach for Liver Cancer.靶向肝癌干细胞：一种肝癌的替代治疗方法
Cancers (Basel). 2020 Sep 24;12(10):2746. doi: 10.3390/cancers12102746.
神经干细胞向成熟神经元的分化：调控机制与生物技术应用。
Biotechnol Adv. 2018 Nov 15;36(7):1946-1970. doi: 10.1016/j.biotechadv.2018.08.002. Epub 2018 Aug 3.
4
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.BMP 和 WNT 信号通过 LEF1 在成年海马神经干细胞和祖细胞的神经元特化中合作。
Sci Rep. 2018 Jun 18;8(1):9241. doi: 10.1038/s41598-018-27581-0.
5
Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.组合敲除 RARα、RARβ 和 RARγ 完全阻断了视黄酸在小鼠胚胎干细胞中的转录反应。
J Biol Chem. 2018 Jul 27;293(30):11891-11900. doi: 10.1074/jbc.RA118.001951. Epub 2018 May 30.
6
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons and in Human Induced Pluripotent and Neural Stem Cells.BMP/SMAD 通路促进中脑多巴胺能神经元的神经发生，以及在人诱导多能干细胞和神经干细胞中。
J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10.
7
BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain.骨形态发生蛋白4/白血病抑制因子或视黄酸/福斯高林抑制成年猴脑源性神经干细胞的增殖。
Stem Cells Int. 2017;2017:7012405. doi: 10.1155/2017/7012405. Epub 2017 Sep 20.
8
Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy.从人胚胎干细胞高效快速分化人神经干细胞用于细胞治疗
Stem Cells Int. 2017;2017:9405204. doi: 10.1155/2017/9405204. Epub 2017 Sep 18.
9
Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis.蛋白S调节神经干细胞的静止和神经发生。
Stem Cells. 2017 Mar;35(3):679-693. doi: 10.1002/stem.2522. Epub 2016 Nov 8.
10
Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.具有时间释放能力的可追踪纳米颗粒递送来递送小干扰 RNA 和维甲酸以控制神经干细胞分化用于阿尔茨海默病治疗。
Adv Mater. 2016 Aug;28(30):6345-52. doi: 10.1002/adma.201600554. Epub 2016 May 11.