用于核成像的99mTc-白蛋白胶体对白细胞的吞噬标记。

Phagocytic labeling of leukocytes with 99mTc-albumin colloid for nuclear imaging.

作者信息

Marcus C S, Kuperus J H, Butler J A, Henneman P L, Salk R D, Chen B Y, Vivian M R, Yamanaka L M

机构信息

Division of Nuclear Medicine, Harbor-UCLA Medical Center, Torrance 90509.

出版信息

Int J Rad Appl Instrum B. 1988;15(6):673-82. doi: 10.1016/0883-2897(88)90060-8.

DOI:10.1016/0883-2897(88)90060-8

PMID:3251900

Abstract

A procedure is described for the phagocytic labeling of white blood cells (WBC) with high specific activity 99mTc--albumin colloid (TAC). The preparation contains approximately equal activities of granulocytes and monocytes. Heparinized whole blood (40 cm3) yields a preparation containing a total of 148-222 MBq (4-6 mCi) TAC-WBC including about 20% free TAC. The complete preparation time is 75 min. Imaging is completed 30 min to 4 h post administration of the TAC-WBC. Quality control methods and imaging protocols are described.

摘要

本文描述了一种用高比活度99mTc-白蛋白胶体（TAC）对白细胞（WBC）进行吞噬标记的方法。该制剂中粒细胞和单核细胞的活性大致相等。40立方厘米的肝素化全血可制备出一种制剂，其中含有总量为148 - 222兆贝克勒尔（4 - 6毫居里）的TAC-WBC，包括约20%的游离TAC。整个制备时间为75分钟。在注射TAC-WBC后30分钟至4小时内完成成像。文中还描述了质量控制方法和成像方案。