Gerência de Controle de Zoonoses, Prefeitura de Belo Horizonte, Belo Horizonte, Brasil.
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Cad Saude Publica. 2020 Jun 8;36(6):e00060219. doi: 10.1590/0102-311X00060219. eCollection 2020.
This research applies indicators concerning control of the visceral leishmaniasis canine reservoir in the city of Belo Horizonte, Minas Gerais State, Brazil. Data were obtained from the Zoonoses Control Information System (SCZOO) and the Brazilian Information System on Diseases of Notification (SINAN) database. First we analyzed (i) existing associations between canine epidemiological indicators, where the dependent variable was the canine seroprevalence A (2007 to 2013), and the independent variables were, as follows: canine seroprevalence B (2006 to 2012); percentage of positive dogs by ELISA test reagents that were not euthanized; the relationship between the human and canine population; canine population testing coverage by census surveys; and the years of study (2006 to 2013); (ii) then, we examined the association between human visceral leishmaniasis (HVL) cases between 2007 to 2013 and the mentioned variables related to dogs and years. Statistical analysis was done by a generalized linear model (GLM). One unit increases in canine seroprevalence B and canine seroprevalence A were associated to 13% and 12% increases in HVL rates, respectively. The increase in one human/dog ratio unit was associated with a 13% decrease in HVL rates. Canine seroprevalence, human/dog ratio and non-euthanasia of ELISA-reactive dogs in the environment were adequate indicators for analyzing the canine enzootic transmission and the occurrence of HVL cases.
本研究应用了巴西米纳斯吉拉斯州贝洛奥里藏特市控制内脏利什曼病犬类储存库的指标。数据来自于动物传染病控制信息系统（SCZOO）和巴西传染病报告信息系统（SINAN）数据库。首先，我们分析了（i）犬类流行病学指标之间的现有关联，其中因变量为犬血清阳性率 A（2007 年至 2013 年），自变量为：犬血清阳性率 B（2006 年至 2012 年）；用 ELISA 试剂检测出的阳性犬但未被安乐死的比例；人类和犬类人口之间的关系；犬类普查检测覆盖率；以及研究年份（2006 年至 2013 年）；（ii）然后，我们检查了 2007 年至 2013 年期间人类内脏利什曼病（HVL）病例与上述与犬类和年份相关的变量之间的关联。统计分析采用广义线性模型（GLM）。犬血清阳性率 B 和犬血清阳性率 A 每增加一个单位，分别与 HVL 发病率增加 13%和 12%相关。人与犬比例每增加一个单位，HVL 发病率降低 13%。犬血清阳性率、人与犬的比例和环境中非安乐死的 ELISA 反应性犬是分析犬类地方性传播和 HVL 病例发生的适当指标。
