通过偶氮-康普瑞他汀A4和光动力喜树碱进行异构化依赖性癌症治疗的偶氮苯光开关
Azobenzene Photoswitch for Isomerization-Dependent Cancer Therapy via Azo-Combretastatin A4 and Phototrexate.
作者信息
Mulatihan Dinaer, Guo Tao, Zhao Yanjun
机构信息
School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin, China.
Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
出版信息
Photochem Photobiol. 2020 Nov;96(6):1163-1168. doi: 10.1111/php.13292. Epub 2020 Jul 6.
The adverse effects of chemotherapeutic drugs to healthy organs/cells greatly limit their clinical efficacy and patient compliance. The unique behavior of azobenzene photoswitch offers a remarkable tool to address the side effects of chemotherapeutic drugs. The azobenzene moiety has been integrated within some chemotherapeutic drugs to realize photo-triggered activation of drug cytotoxicity. However, the clinical translation of these agents has been facing a few barriers. In this short review, we present our viewpoints on potential solutions to address the following challenges associated with azobenzene-based photoswitchable chemotherapeutic drugs, including poor tissue penetration of light, hypoxia-induced drug degradation in solid tumor and the autonomous cis-trans relaxation.
化疗药物对健康器官/细胞的不良反应极大地限制了它们的临床疗效和患者的依从性。偶氮苯光开关的独特特性为解决化疗药物的副作用提供了一个卓越的工具。偶氮苯部分已被整合到一些化疗药物中，以实现药物细胞毒性的光触发激活。然而，这些药物的临床转化面临着一些障碍。在这篇简短的综述中，我们针对与基于偶氮苯的光开关化疗药物相关的以下挑战提出了潜在解决方案的观点，这些挑战包括光的组织穿透性差、实体瘤中缺氧诱导的药物降解以及自发的顺反弛豫。
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