线粒体动力学在免疫细胞中的基本功能。
The essential functions of mitochondrial dynamics in immune cells.
作者信息
Xie Jia-Huan, Li Yi-Yuan, Jin Jin
机构信息
MOE Laboratory of Biosystem Homeostasis and Protection and Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China.
Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 210096, China.
出版信息
Cell Mol Immunol. 2020 Jul;17(7):712-721. doi: 10.1038/s41423-020-0480-1. Epub 2020 Jun 10.
Abstract
Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy, and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an important role in energy production, cell division, cell differentiation, and cell death. In the past decade, numerous studies have revealed the importance of mitochondrial metabolism in immunity, and mitochondrial dynamics are essential for immune responses mediated by various cell types. In this review, we mainly discuss the role of mitochondrial dynamics in activation, differentiation, cytokine production, and the activity of related pathways in immune cells, particularly T cells, B cells, and other cells involved in the innate immune response.
摘要
线粒体由于分裂、融合、运输和线粒体自噬而成为高度可移动的细胞器，这些过程被称为线粒体动力学。线粒体动力学在能量产生、细胞分裂、细胞分化和细胞死亡中发挥重要作用。在过去十年中，大量研究揭示了线粒体代谢在免疫中的重要性，并且线粒体动力学对于由各种细胞类型介导的免疫反应至关重要。在本综述中，我们主要讨论线粒体动力学在免疫细胞，特别是T细胞、B细胞和其他参与固有免疫反应的细胞的激活、分化、细胞因子产生以及相关途径活性中的作用。
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