Nanjing University of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China; Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China.
Nanjing University of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Cell Immunol. 2024 Sep-Oct;403-404:104864. doi: 10.1016/j.cellimm.2024.104864. Epub 2024 Aug 26.
Mitochondria are highly dynamic organelles that maintain their homeostasis through mitochondrial dynamics. Mitochondrial fusion and fission are two important processes of mitochondrial dynamics. There is accumulating evidence that mitochondrial fusion and fission play an important role in the development of immune-mediated inflammatory diseases. This article provides a brief review of the essential role of mitochondrial fusion and fission in immune-mediated inflammatory diseases. It will provide a novel perspective and direction for the elucidation of the pathogenesis and treatment of immune-mediated inflammatory diseases.
线粒体是高度动态的细胞器，通过线粒体动态维持其内稳态。线粒体融合和裂变是线粒体动态的两个重要过程。越来越多的证据表明，线粒体融合和裂变在免疫介导的炎症性疾病的发展中起着重要作用。本文简要综述了线粒体融合和裂变在免疫介导的炎症性疾病中的重要作用。它将为阐明免疫介导的炎症性疾病的发病机制和治疗提供新的视角和方向。
