Lo Kenneth, Huang Yu-Qing, Liu Lin, Yu Yu-Ling, Chen Chao-Lei, Huang Jia-Yi, Feng Ying-Qing
Department of Cardiology, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong Provincial People's Hospital, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Academy of Medical Sciences, South China University of Technology School of Medicine, Guangzhou, People's Republic of China.
Centre for Global Cardiometabolic Health, Department of Epidemiology, Brown University, Providence, Rhode Island, USA.
Diabetes Metab Syndr Obes. 2020 May 14;13:1661-1668. doi: 10.2147/DMSO.S256133. eCollection 2020.
Although poor sleep health and vitamin D deficiency may be associated with diabetes and hypertension, whether this association shows a trend depending on vitamin D concentration is unclear.
We analyzed data from 10,742 participants (4997 men) from the 2007-2014 National Health and Nutrition Examination Survey. Abnormal sleep pattern (ie, short sleep duration, sleep complaint, and/or sleep disorder), lifestyle factors, serum vitamin D level, and the status of diabetes and hypertension were assessed. Logistic regression was performed to estimate the odds ratio (OR) and 95% confidence interval (CI).
Serum vitamin D significantly interacted with short sleep duration and abnormal sleep pattern (both p = 0.003) on the association with diabetes in men. Short sleep duration (OR: 1.82, 95% CI = 1.29, 2.57) and abnormal sleep pattern (OR: 1.95, 95% CI = 1.38, 2.77) were associated with diabetes in men with serum vitamin D of >75 nmol/L. Serum vitamin D significantly interacted with sleep complaint on the association with hypertension in men and women (both p < 0.05). The magnitude of association between sleep complaint and hypertension in men was stronger when serum vitamin D level was <50 nmol/L (OR: 2.26, 95% CI = 1.57, 3.25) than when the level was >75 nmol/L (OR: 1.28, 95% CI = 0.90, 1.83). Similarly, the magnitude of association between sleep complaint and hypertension in women was stronger when serum vitamin D level was <50 nmol/L (OR: 2.09, 95% CI = 1.53, 2.86) than when the level was >75 nmol/L (OR: 1.64, 95% CI = 0.98, 2.72). No significant interactions were observed between serum vitamin D level and other sleep variables.
Abnormal sleep pattern is associated with a high risk of diabetes and hypertension. The relationship between sleep complaint and hypertension may be strong in people with vitamin D deficiency, and this observation should be verified by prospective studies.
尽管睡眠健康状况不佳和维生素D缺乏可能与糖尿病和高血压有关，但这种关联是否随维生素D浓度呈现某种趋势尚不清楚。
我们分析了2007 - 2014年美国国家健康与营养检查调查中10742名参与者（4997名男性）的数据。评估了异常睡眠模式（即睡眠时间短、睡眠问题和/或睡眠障碍）、生活方式因素、血清维生素D水平以及糖尿病和高血压状况。进行逻辑回归以估计比值比（OR）和95%置信区间（CI）。
在男性中，血清维生素D在与糖尿病的关联上与睡眠时间短和异常睡眠模式存在显著交互作用（两者p = 0.003）。血清维生素D>75 nmol/L的男性中，睡眠时间短（OR：1.82，95% CI = 1.29，2.57）和异常睡眠模式（OR：1.95，95% CI = 1.38，2.77）与糖尿病相关。血清维生素D在男性和女性与高血压的关联上与睡眠问题存在显著交互作用（两者p < 0.05）。血清维生素D水平<50 nmol/L时，男性睡眠问题与高血压之间的关联强度（OR：2.26，95% CI = 1.57，3.25）强于维生素D水平>75 nmol/L时（OR：1.28，95% CI = 0.90，1.83）。同样，血清维生素D水平<50 nmol/L时，女性睡眠问题与高血压之间的关联强度（OR：2.09，95% CI = 1.53，2.86）强于维生素D水平>75 nmol/L时（OR：1.64，95% CI = 0.98，2.72）。未观察到血清维生素D水平与其他睡眠变量之间存在显著交互作用。
异常睡眠模式与糖尿病和高血压的高风险相关。维生素D缺乏人群中睡眠问题与高血压之间的关系可能较强，这一观察结果应通过前瞻性研究加以验证。
