Tamburello Adriana, Bruno Giovanni, Marando Marco
General Internal Medicine, Ospedale Regionale di Lugano, Lugano, Switzerland.
Eur J Case Rep Intern Med. 2020 May 4;7(6):001692. doi: 10.12890/2020_001692. eCollection 2020.
In December 2019, a novel coronavirus called SARS-CoV-2 was reported to be responsible for a cluster of acute atypical respiratory pneumonia cases in Wuhan, in Hubei province, China. The disease caused by this virus is called COVID-19 (coronavirus disease 2019). The virus is transmitted between humans and the outbreak was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. Coagulopathy is a common abnormality in patients with COVID-19 due to inflammation, hypoxia, immobilisation, endothelial damage and diffuse intravascular coagulation. However, the data on this topic are still limited. Here we report the case of a man presenting with pneumonia complicated by bilateral pulmonary embolism.
SARS-CoV-2 is a novel infectious agent that causes COVID-19, which can manifest in several ways, affecting endothelial cells and most organs.There is growing evidence that SARS-CoV-2-mediated endothelial damage is due to direct viral injury and the systemic inflammatory response, possibly together with a cytokine storm.As endothelial damage can manifest as thromboembolic disease, such as pulmonary thromboembolism, appropriate anti-thrombotic preventive strategies should be followed, and proper screening and treatment for thromboembolic complications should be implemented.
2019年12月，一种名为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的新型冠状病毒被报告为中国湖北省武汉市一组急性非典型肺炎病例的病因。这种病毒引起的疾病被称为2019冠状病毒病（COVID-19）。该病毒在人与人之间传播，世界卫生组织（WHO）于2020年3月11日宣布此次疫情为大流行。由于炎症、缺氧、制动、内皮损伤和弥散性血管内凝血，凝血功能障碍在COVID-19患者中是一种常见的异常情况。然而，关于这一主题的数据仍然有限。在此，我们报告一例患有肺炎并伴有双侧肺栓塞的男性病例。
SARS-CoV-2是一种新型感染因子，可导致COVID-19，其表现形式多样，可影响内皮细胞和大多数器官。越来越多的证据表明，SARS-CoV-2介导的内皮损伤是由于直接病毒损伤和全身炎症反应，可能还伴有细胞因子风暴。由于内皮损伤可表现为血栓栓塞性疾病，如肺血栓栓塞，应遵循适当的抗血栓预防策略，并对血栓栓塞并发症进行适当的筛查和治疗。
