Zaigham Suneela, Persson Margaretha, Jujic Amra, Frantz Sophia, Borné Yan, Malinovschi Andrei, Wollmer Per, Engström Gunnar
Dept of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Dept of Cardiology, Lund University, Skåne University Hospital, Malmö, Sweden.
ERJ Open Res. 2020 Jun 1;6(2). doi: 10.1183/23120541.00356-2019. eCollection 2020 Apr.
Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide ( ) and impulse oscillometry (IOS) in relation to SAF.
Participants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; , n=3889; IOS, n=3970). Linear regression was used to assess changes in lung function (as measured by spirometry (forced expiratory volume in 1 s (FEV), forced vital capacity (FVC) and FEV/FVC), and IOS (resistance measured at 5 ( ) and 20 Hz ( ), - , area of reactance, reactance measured at 5 Hz ( ), and resonant frequency)) by a 1-sd increase in SAF.
FEV, FVC and were significantly and inversely associated with SAF after adjustment for potential confounding factors (per 1-sd increase in SAF: FEV -0.03 L (95% CI -0.04- -0.02 L), p<0.001; FVC -0.03 L (95% CI -0.05- -0.02 L), p<0.001; -0.07 mmol·min·kPa (95% CI -0.11- -0.03 mmol·min·kPa), p<0.001). This association was also found in nonsmokers and in non-COPD subjects. Pulmonary reactance ( ) but not pulmonary resistance ( , and - ) was significantly associated with SAF (per 1-sd increase in SAF: -0.001 kPa·L·s (95% CI -0.003-0.00 kPa·L·s), p=0.042), which was mirrored in non-COPD patients but not in current nonsmokers.
AGE accumulation, as measured by SAF, is significantly associated with lung function decrements indicative of changes in the lung parenchyma.
晚期糖基化终产物（AGEs）与慢性阻塞性肺疾病（COPD）的病理生理学有关。然而，尚未详细探讨通过皮肤自发荧光（SAF）测量的皮肤中AGE积累与健康受试者肺功能之间的关联。我们利用一项基于人群的针对50至64岁人群的研究，来评估肺活量测定、肺一氧化碳弥散量（）和脉冲振荡法（IOS）与SAF的关系。
从瑞典心肺生物影像研究（SCAPIS）队列中纳入有SAF、肺功能及潜在混杂变量信息的参与者（肺活量测定，n = 4111；，n = 3889；IOS，n = 3970）。采用线性回归评估SAF每增加1个标准差时肺功能的变化（通过肺活量测定（第1秒用力呼气量（FEV）、用力肺活量（FVC）和FEV/FVC）、及IOS（5（）和20 Hz（）时测量的阻力、-、电抗面积、5 Hz时测量的电抗（）和共振频率））。
在对潜在混杂因素进行调整后，FEV、FVC和与SAF显著负相关（SAF每增加1个标准差：FEV -0.03 L（95%CI -0.04 - -0.02 L），p<0.001；FVC -0.03 L（95%CI -0.05 - -0.02 L），p<0.001；-0.07 mmol·min·kPa（95%CI -0.11 - -0.03 mmol·min·kPa），p<0.001）。这种关联在非吸烟者和非COPD受试者中也有发现。肺电抗（）而非肺阻力（、和-）与SAF显著相关（SAF每增加1个标准差：-0.001 kPa·L·s（95%CI -0.003 - 0.00 kPa·L·s），p = 0.042），这在非COPD患者中得到体现，但在当前非吸烟者中未体现。
通过SAF测量的AGE积累与提示肺实质变化的肺功能下降显著相关。
