老年人皮肤自发荧光与白细胞计数的相关性研究。
Association Between Skin Autofluorescence and White Blood Cell Counts in Older Adults.
机构信息
Department of Pharmacotherapy, School of Pharmacy, Shujitsu University, Okayama, Japan.
Pharmaceutical Care and Health Sciences, School of Pharmacy, Shujitsu University, Okayama, Japan.
出版信息
In Vivo. 2023 Nov-Dec;37(6):2734-2742. doi: 10.21873/invivo.13384.
BACKGROUND/AIM: Advanced glycation end products (AGEs) accumulate in the body with increasing age. However, their excessive accumulation may lead to various inflammatory and chronic diseases. While it is common for older adults to experience various comorbidities, there is a scarcity of published literature documenting the specific impact of ageing and comorbidities on AGEs in this population. The present study aimed to retrospectively evaluate the correlation among AGEs in the skin, calendar age, and comorbidities in older adults.
PATIENTS AND METHODS
Accumulated AGEs in the skin were assessed by non-invasive measurement of skin autofluorescence (SAF) inside the forearm. This retrospective study included individuals who underwent SAF measurements at Shujitsu University Community Pharmacy with or without a prescription from October 2019 to October 2021. Subsequently, the associations between SAF, calendar age, comorbidities, and blood test parameters were investigated.
RESULTS
SAF showed a positive correlation with calendar age for all enrolled participants; the correlation weakened for participants aged ≥50 years and plateaued for those aged ≥60 years. Furthermore, we observed a significant increase in SAF among all participants with comorbidities compared to those without comorbidities. By contrast, among participants aged ≥50 years, SAF did not show a significant association with comorbidities. However, SAF was significantly positively correlated with white blood cell (WBC) counts in these aged populations.
CONCLUSION
The non-invasive assessment of SAF holds promise in evaluating changes in the physical condition associated with WBC counts among older adults.
背景/目的：随着年龄的增长，体内的晚期糖基化终产物（AGEs）会不断积累。然而，AGEs 的过度积累可能会导致各种炎症和慢性疾病。虽然老年人经常会出现多种合并症，但关于衰老和合并症对该人群中 AGEs 的具体影响，相关文献却十分匮乏。本研究旨在回顾性评估老年人皮肤 AGEs 与日历年龄和合并症之间的相关性。
患者和方法
通过非侵入性测量前臂皮肤内的皮肤自发荧光（SAF）来评估皮肤中积累的 AGEs。这项回顾性研究纳入了 2019 年 10 月至 2021 年 10 月在 Shujitsu 大学社区药房进行 SAF 测量的患者，无论是否有处方。随后，研究调查了 SAF 与日历年龄、合并症和血液测试参数之间的关联。
结果
所有入组参与者的 SAF 均与日历年龄呈正相关；≥50 岁参与者的相关性减弱，≥60 岁的参与者则趋于平稳。此外，我们观察到所有合并症患者的 SAF 均明显高于无合并症患者。相比之下，≥50 岁的参与者中，SAF 与合并症之间无显著关联。然而，在这些年龄较大的人群中，SAF 与白细胞（WBC）计数呈显著正相关。
结论
非侵入性评估 SAF 有望评估与 WBC 计数相关的老年人体质变化。
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