Department of Metabolic Medicine, Osaka Kaisei Hospital, Osaka, Japan.
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, Osaka, Japan.
J Diabetes Complications. 2018 Sep;32(9):839-844. doi: 10.1016/j.jdiacomp.2018.06.009. Epub 2018 Jun 22.
Tissue accumulatedadvanced glycation end products (AGEs) can be evaluated non-invasively by an autofluorescence reader as skin autofluorescence (skin AF)·The present study investigated whether skin AF is associated with diabetic micro- and macroangiopathies in Japanese patients with type 2 diabetes mellitus (T2DM).
Skin AF was measured in 193 enrolled Japanese patients with T2DM and 24 enrolled healthy non-diabetic subjects by using the AGE reader®. Diabetic micro- and macroangiopathies were evaluated in the T2DM patients.
Skin AF was significantly increased in patients with T2DM than in age- and sex-matched non-diabetic controls (2.35 ± 0.51 [mean ± SD] and 1.91 ± 0.29, respectively, p = 0.001). In subjects with T2DM, skin AF was associated with age, pack-years of smoking, and eGFR (estimated glomerular filtration rate) independently. Skin AF was significantly increased in patients with diabetic retinopathy, neuropathy, nephropathy, and macroangiopathy than in those without them, and significantly associated with the number of diabetic complications. Moreover, skin AF was an independent predictor for diabetic retinopathy, neuropathy, and nephropathy but not macroangiopathy, after adjusting for major traditional risk factors.
Skin AF is an independent predictor for diabetic retinopathy, neuropathy and nephropathy in Japanese patients with T2DM.
组织中积累的晚期糖基化终产物（AGEs）可以通过自动荧光阅读器（皮肤 autofluorescence，皮肤 AF）进行非侵入性评估。本研究旨在探讨日本 2 型糖尿病（T2DM）患者的皮肤 AF 是否与糖尿病的微血管和大血管病变相关。
使用 AGE 阅读器®对 193 名日本 T2DM 患者和 24 名健康非糖尿病对照者进行皮肤 AF 测量。在 T2DM 患者中评估糖尿病的微血管和大血管病变。
T2DM 患者的皮肤 AF 明显高于年龄和性别匹配的非糖尿病对照组（分别为 2.35±0.51[平均值±标准差]和 1.91±0.29，p=0.001）。在 T2DM 患者中，皮肤 AF 与年龄、吸烟包年数和 eGFR（估计肾小球滤过率）独立相关。患有糖尿病视网膜病变、神经病变、肾病和大血管病变的患者的皮肤 AF 明显高于无这些病变的患者，并且与糖尿病并发症的数量显著相关。此外，在校正主要传统危险因素后，皮肤 AF 是糖尿病视网膜病变、神经病变和肾病的独立预测因子，但不是大血管病变的独立预测因子。
在日本 T2DM 患者中，皮肤 AF 是糖尿病视网膜病变、神经病变和肾病的独立预测因子。
